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Literature summary for 4.4.1.20 extracted from
- Purification and properties of leukotriene C4 synthase from guinea pig lung microsomes (1990), Methods Enzymol., 187, 335-337.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| leukotriene C4 | IC50: 0.0021 mM, inhibits reaction with leukotriene C4 methyl ester | Cavia porcellus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.015 | - |
leukotriene A4 methyl ester | 22°C, pH 7.6 | Cavia porcellus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Cavia porcellus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Cavia porcellus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | - |
Cavia porcellus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene A4 + glutathione | - |
Cavia porcellus | leukotriene C4 + H2O | - |
? | |
| leukotriene A4 methyl ester + glutathione | - |
Cavia porcellus | leukotriene C4 methyl ester + H2O | - |
? | |
| leukotriene A4 methyl ester + glutathione | - |
Cavia porcellus | leukotriene C4 methyl ester | - |
? | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0021 | - |
IC50: 0.0021 mM, inhibits reaction with leukotriene C4 methyl ester | Cavia porcellus | leukotriene C4 | |
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