BRENDA - Enzyme Database
show all sequences of 4.4.1.17

Import of cytochrome c heme lyase into mitochondria: a novel pathway into the intermembarne space

Lill, R.; Stuart, R.A.; Drygas, M.E.; Nargang, F.E.; Neupert, W.; EMBO J. 11, 449-456 (1992)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
integral to membrane
-
Neurospora crassa
-
-
mitochondrial inner membrane
-
Neurospora crassa
5743
-
mitochondrial intermembrane space
novel, non-conservative import pathway: the enzyme precursor is translocated into mitochondria using the MOM19-GIP receptor complex in the outer membrane, independent of ATP-hydrolysis and electrochemical potential as external energy source
Neurospora crassa
5758
-
mitochondrion
intermembrane space; novel, non-conservative import pathway: the enzyme precursor is translocated into mitochondria using the MOM19-GIP receptor complex in the outer membrane, independent of ATP-hydrolysis and electrochemical potential as external energy source
Neurospora crassa
5739
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
Apocytochrome c + heme
Neurospora crassa
during its import into mitochondria
?
-
-
-
Organism
Organism
UniProt
Commentary
Textmining
Neurospora crassa
-
wild-type strain 74A
-
Purification (Commentary)
Purification (Commentary)
Organism
partial
Neurospora crassa
Source Tissue
Source Tissue
Commentary
Organism
Textmining
hypha
-
Neurospora crassa
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
Apocytochrome c + heme
catalyzes covalent attachment of heme group to two cysteine residues in the protein
94058
Neurospora crassa
Holocytochrome c
-
-
-
-
Apocytochrome c + heme
during its import into mitochondria
94058
Neurospora crassa
?
-
-
-
-
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
integral to membrane
-
Neurospora crassa
-
-
mitochondrial inner membrane
-
Neurospora crassa
5743
-
mitochondrial intermembrane space
novel, non-conservative import pathway: the enzyme precursor is translocated into mitochondria using the MOM19-GIP receptor complex in the outer membrane, independent of ATP-hydrolysis and electrochemical potential as external energy source
Neurospora crassa
5758
-
mitochondrion
intermembrane space; novel, non-conservative import pathway: the enzyme precursor is translocated into mitochondria using the MOM19-GIP receptor complex in the outer membrane, independent of ATP-hydrolysis and electrochemical potential as external energy source
Neurospora crassa
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
Apocytochrome c + heme
Neurospora crassa
during its import into mitochondria
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
partial
Neurospora crassa
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
hypha
-
Neurospora crassa
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
Apocytochrome c + heme
catalyzes covalent attachment of heme group to two cysteine residues in the protein
94058
Neurospora crassa
Holocytochrome c
-
-
-
-
Apocytochrome c + heme
during its import into mitochondria
94058
Neurospora crassa
?
-
-
-
-
Other publictions for EC 4.4.1.17
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
747125
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Biosynthesis of single thioet ...
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Biochemistry
56
3337-3346
2017
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749183
Mendez
Engineered holocytochrome c s ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
114
2235-2240
2017
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748211
Babbitt
Molecular basis behind inabil ...
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17523-17534
2016
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1
1
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729264
Babbitt
Conserved residues of the huma ...
Homo sapiens
Biochemistry
53
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2014
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1
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12
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12
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1
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2
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2
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729740
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Substrate recognition of holoc ...
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2014
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11
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3
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11
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Babbitt
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730827
San Francisco
Human mitochondrial holocytoch ...
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2013
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715034
Stevens
The mitochondrial cytochrome c ...
Saccharomyces cerevisiae
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585
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2011
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729727
Moore
Mitochondrial cytochrome c syn ...
Saccharomyces cerevisiae
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585
3415-3419
2011
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9
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3
1
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9
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1
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730322
Kleingardner
Comparing substrate specificit ...
Saccharomyces cerevisiae
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2011
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1
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713714
Qidwai
Deletions of Xp provide eviden ...
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715120
Corvest
c-type cytochrome assembly in ...
Saccharomyces cerevisiae
Genetics
186
561-571
2010
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691507
Kemmer
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691983
Drenckhahn
Compensatory growth of healthy ...
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Dev. Cell
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2008
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Mutations of the mitochondrial ...
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2006
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1
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A bacterial cytochrome c heme ...
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651895
Tong
Cytochrome c heme lyase activi ...
Saccharomyces cerevisiae
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273
25695-25702
1998
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653258
Cervera
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1
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651429
Schaefer
Cloning and characterization o ...
Homo sapiens, Mus musculus
Genomics
34
166-172
1996
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2
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Biogenesis of mitochondrial he ...
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94058
Lill
Import of cytochrome c heme ly ...
Neurospora crassa
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Zollner
Molecular cloning and characte ...
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1992
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Drygas
Cloning and analysis of the Ne ...
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1989
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94056
Dumont
Identification and sequence of ...
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1987
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94057
Nicholson
Import of cytochrome c into mi ...
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94055
Enosawa
Localization of enzyme for hem ...
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1986
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