Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.4.1.14 extracted from

  • Lin, L.C.; Hsu, J.H.; Wang, L.C.
    Identification of novel inhibitors of 1-aminocyclopropane-1-carboxylic acid synthase by chemical screening in Arabidopsis thaliana (2010), J. Biol. Chem., 285, 33445-33456.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.4.1.14

Application

Application Comment Organism
agriculture identification of compounds inhibiting ethylene biosynthesis at the step of converting S-adenosylmethionine to 1-aminocyclopropane-1-carboxylic acid by ACC synthase Arabidopsis thaliana

Cloned(Commentary)

Cloned (Comment) Organism
isoform ACS5, expression in Escherichia coli Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
2-(cyclopentylamino)-7,7-dimethyl-7,8-dihydroquinazolin-5(6H)-one inhibition of ethylene biosynthesis at the step of converting S-adenosylmethionine to 1-aminocyclopropane-1-carboxylic acid by ACC synthase Arabidopsis thaliana
2-(cyclopentylamino)-7-(4-methylphenyl)-7,8-dihydroquinazolin-5(6H)-one inhibition of ethylene biosynthesis at the step of converting S-adenosylmethionine to 1-aminocyclopropane-1-carboxylic acid by ACC synthase Arabidopsis thaliana
7-(4-methoxyphenyl)-2-(phenylamino)-7,8-dihydroquinazolin-5(6H)-one inhibition of ethylene biosynthesis at the step of converting S-adenosylmethionine to 1-aminocyclopropane-1-carboxylic acid by ACC synthase Arabidopsis thaliana
aminoethoxyvinylglycine
-
 Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q37001
-
-

Synonyms

Synonyms Comment Organism
ACS5
-
 Arabidopsis thaliana

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000015
-
 7-(4-methoxyphenyl)-2-(phenylamino)-7,8-dihydroquinazolin-5(6H)-one pH 8.0, 25°C Arabidopsis thaliana
0.000023
-
 aminoethoxyvinylglycine pH 8.0, 25°C Arabidopsis thaliana

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0005
-
 pH 8.0, 25°C Arabidopsis thaliana 7-(4-methoxyphenyl)-2-(phenylamino)-7,8-dihydroquinazolin-5(6H)-one
0.0007
-
 pH 8.0, 25°C Arabidopsis thaliana aminoethoxyvinylglycine
0.0014
-
 pH 8.0, 25°C Arabidopsis thaliana 2-(cyclopentylamino)-7-(4-methylphenyl)-7,8-dihydroquinazolin-5(6H)-one
0.0079
-
 pH 8.0, 25°C Arabidopsis thaliana 2-(cyclopentylamino)-7,7-dimethyl-7,8-dihydroquinazolin-5(6H)-one