Literature summary for 4.3.3.7 extracted from

Skovpen, Y.V.; Conly, C.J.; Sanders, D.A.; Palmer, D.R.
Biomimetic design results in a potent allosteric inhibitor of dihydrodipicolinate synthase from Campylobacter jejuni (2016), J. Am. Chem. Soc., 138, 2014-2020 .

Search for more literature for 4.3.3.7

Application

Application	Comment	Organism
drug development	the enzyme is a target for antibiotics	Campylobacter jejuni
pharmacology	the enzyme is a target for antibiotics	Campylobacter jejuni

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystals are grown in a solution of 0.28 M sodium acetate, 30% PEG 4000, 0.1 M TRIS pH 8.5 using the hanging drop vapor diffusion method	Campylobacter jejuni

Protein Variants

Protein Variants	Comment	Organism
Y110F	the mutant enzyme is resistant to lysine inhibition	Campylobacter jejuni

Inhibitors

Inhibitors	Comment	Organism	Structure
bislysine	bislysine is a mixed partial inhibitor with respect to the first substrate, pyruvate, and a noncompetitive partial inhibitor with respect to L-aspartate-4-semialdehyde	Campylobacter jejuni
L-lysine	allosteric inhibitor	Campylobacter jejuni

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
pyruvate + L-aspartate-4-semialdehyde	Campylobacter jejuni	-	(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Campylobacter jejuni	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Campylobacter jejuni

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pyruvate + L-aspartate-4-semialdehyde	-	Campylobacter jejuni	(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O	-	?

Synonyms

Synonyms	Comment	Organism
DHDPS	-	Campylobacter jejuni

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0002	-	bislysine	pH 8.0, 25°C	Campylobacter jejuni

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Release 2023.1 (January 2023)