Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,2'-benzene-1,3-diylbis(oxoacetic acid) | - |
Escherichia coli | |
dimethyl 2,2'-benzene-1,3-diylbis[(hydroxyimino)ethanoate] | - |
Escherichia coli | |
additional information | new constrained inhibitors of DHDPS identified and tested, time-dependent inhibition and substrate protection, dimethyl 2,2'-benzene-1,3-diylbis[(hydroxyimino)ethanoate] discovered as a relatively potent inhibitor of DHDPS enzyme, validates constrained acyclic-intermediate model as a potential inhibitor lead, modifications of the aromatic ring are possible and may result in improvements in activity | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0A6L2 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-aspartate 4-semialdehyde + pyruvate | diketopimelic acid derivatives designed as mimics of the acyclic enzyme-bound condensation product of (S)-aspartate 4-semialdehyde and pyruvate, inhibition analysis | Escherichia coli | dihydrodipicolinate + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DHDPS | - |
Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.33 | - |
dimethyl 2,2'-benzene-1,3-diylbis[(hydroxyimino)ethanoate] | 15% inhibition at 1 mM, binding with the active site lysine residue, kinetic analysis corresponds to slow-binding model of inhibition | Escherichia coli | |
2.96 | - |
2,2'-benzene-1,3-diylbis(oxoacetic acid) | 49% inhibition at 5 mM, mimics the substrate pyruvate, binding with the active site lysine residue, slow inhibition | Escherichia coli |