Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1SR,3R,5S)-1-hydroxy-3,5-bis(methoxycarbonyl)thiomorpholin-1-ium | 30 mM, 18% inhibition | Escherichia coli | |
(1SS,3R,5S)-1-hydroxy-3,5-bis(methoxycarbonyl)thiomorpholin-1-ium | 9 mM, 48% inhibition | Escherichia coli | |
(2R,6S)-piperidine-2,6-dicarboxylic acid | IC50: 20 mM, 83% inhibition at 50 mM | Escherichia coli | |
(3R,5R)-thiomorpholine-3,5-dicarboxylic acid | 50 mM, 32% inhibition | Escherichia coli | |
(3R,5R)-thiomorpholine-3,5-dicarboxylic acid 1,1-dioxide | 50 mM, 11% inhibition | Escherichia coli | |
(3R,5S)-thiomorpholine-3,5-dicarboxylic acid 1,1-dioxide | 50 mM, 14% inhibition | Escherichia coli | |
4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid | i.e. chelidamic acid, IC50: 22 mM, 99% inhibition at 50 mM, uncompetitive inhibitor with respect to both substrates | Escherichia coli | |
dimethyl (3R,5R)-thiomorpholine-3,5-dicarboxylate 1,1-dioxide | 50 mM, 12% inhibition | Escherichia coli | |
dimethyl (3R,5S)-thiomorpholine-3,5-dicarboxylate | 50 mM, 36% inhibition | Escherichia coli | |
dimethyl chelidamate | IC50: 14 mM. 99% inhibition at 50 mM, noncompetitive with respect to both substrates | Escherichia coli | |
dimethyl piperidine-2,6-dicarboxylate | - |
Escherichia coli | |
dipicolinic acid | IC50: 20 mM, competitive inhibitor | Escherichia coli | |
additional information | no inhibition by dipicolinic acid methyl ester, (3R,5S)-thiomorpholine-3,5-dicarboxylic acid compound 20b, (3R,5R)-thiomorpholine-3,5-dicarboxylic acid, compound 23, compound 24b, dimethyl (3R,5S)thiomorpholine-3,5-dicarboxylate 1,1-dioxide | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.14 | - |
L-aspartate 4-semialdehyde | pH 8.0 | Escherichia coli | |
0.38 | - |
pyruvate | pH 8.0 | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate 4-semialdehyde + pyruvate | - |
Escherichia coli | dihydrodipicolinate + H2O | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
6.9 | - |
dimethyl chelidamate | with respect to pyruvate | Escherichia coli | |
14 | - |
dimethyl chelidamate | with respect to L-aspartate 4-semialdehyde | Escherichia coli | |
22 | - |
4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid | with respect to pyruvate | Escherichia coli | |
24.8 | - |
4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid | with respect to L-aspartate 4-semialdehyde | Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
14 | - |
IC50: 14 mM. 99% inhibition at 50 mM, noncompetitive with respect to both substrates | Escherichia coli | dimethyl chelidamate | |
20 | - |
IC50: 20 mM, 83% inhibition at 50 mM | Escherichia coli | (2R,6S)-piperidine-2,6-dicarboxylic acid | |
20 | - |
IC50: 20 mM, competitive inhibitor | Escherichia coli | dipicolinic acid | |
22 | - |
i.e. chelidamic acid, IC50: 22 mM, 99% inhibition at 50 mM, uncompetitive inhibitor with respect to both substrates | Escherichia coli | 4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid |