BRENDA - Enzyme Database show
show all sequences of 4.3.3.6

Assembly of the eukaryotic PLP-synthase complex from Plasmodium and activation of the Pdx1 enzyme

Guedez, G.; Hipp, K.; Windeisen, V.; Derrer, B.; Gengenbacher, M.; Böttcher, B.; Sinning, I.; Kappes, B.; Tews, I.; Structure 20, 172-184 (2012)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
His-tagged subunits Pdx1 and Pdx2 expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL
Plasmodium berghei
His-tagged subunits Pdx1 and Pdx2 expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL
Plasmodium falciparum
Crystallization (Commentary)
Crystallization
Organism
chimeric complex of Pdx2 and Pdx1 from Plasmodium berghei
Plasmodium falciparum
Pdx1, chimeric complex of Pdx1 and Pdx2 from Plasmodium falciparum
Plasmodium berghei
Engineering
Amino acid exchange
Commentary
Organism
H196N
Pdx2, catalytically inactive
Plasmodium falciparum
H199N
Pdx2
Plasmodium berghei
L82A
Pdx1
Plasmodium berghei
M103A
Pdx1
Plasmodium berghei
M103F
Pdx1
Plasmodium berghei
M148L
Pdx1
Plasmodium berghei
M19V
Pdx1
Plasmodium berghei
M46I
Pdx1
Plasmodium berghei
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Plasmodium berghei
Q4Z0E8
-
-
Plasmodium falciparum
-
-
-
Purification (Commentary)
Commentary
Organism
immobilized metal ion affinity chromatography (Ni2+), gel filtration
Plasmodium berghei
immobilized metal ion affinity chromatography (Ni2+), gel filtration
Plasmodium falciparum
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.00025
-
L82A mutant Pdx1, NH4Cl as NH3+ donor, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.00031
-
M103A mutant Pdx1, NH4Cl as NH3+ donor, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.00042
-
M103A mutant Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0007
-
Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium falciparum
0.0008
-
M148L mutant Pdx1, NH4Cl as NH3+ donor, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0009
-
Pdx1, NH4Cl as NH3+ donor, pyridoxal 5'-phosphate synthesis, pH 8, 37°C; Plasmodium falciparum Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0009
-
Pdx1/Plasmodium berghei Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium falciparum
0.0011
-
Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0012
-
L82A mutant Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0013
-
Pdx1/Plasmodium falciparum Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0013
-
Plasmodium berghei Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium falciparum
0.0015
-
M46I mutant Pdx1, NH4Cl as NH3+ donor, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0018
-
M19V mutant Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.002
-
M19V mutant Pdx1, NH4Cl as NH3+ donor, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0028
-
M46I mutant Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0037
-
M148L mutant Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.087
-
M19V mutant Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
0.115
-
L82A mutant Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
0.126
-
M103F mutant Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
0.15
-
Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
0.175
-
Plasmodium falciparum Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
0.175
-
Pdx1/Plasmodium berghei Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium falciparum
0.178
-
M103A mutant Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
0.229
-
M148L mutant Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
0.233
-
Pdx1/Plasmodium falciparum Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
0.233
-
Plasmodium berghei Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium falciparum
0.26
-
Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium falciparum
0.284
-
M46I mutant Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-ribose 5-phosphate + glyceraldehyde 3-phosphate + L-glutamine
-
726499
Plasmodium falciparum
pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate
-
-
-
?
D-ribose 5-phosphate + glyceraldehyde 3-phosphate + L-glutamine
-
726499
Plasmodium berghei
pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate
-
-
-
?
D-ribose 5-phosphate + glyceraldehyde 3-phosphate + NH4+
in the absence of Pdx2
726499
Plasmodium falciparum
pyridoxal 5'-phosphate + 4 H2O + phosphate
-
-
-
?
D-ribose 5-phosphate + glyceraldehyde 3-phosphate + NH4+
in the absence of Pdx2
726499
Plasmodium berghei
pyridoxal 5'-phosphate + 4 H2O + phosphate
-
-
-
?
Subunits
Subunits
Commentary
Organism
homododecamer
Pdx1, random association pattern of up to 12 Pdx2 subunits to the Pdx1 dodecamer
Plasmodium berghei
homododecamer
Pdx1, random association pattern of up to 12 Pdx2 subunits to the Pdx1 dodecamer
Plasmodium falciparum
Cloned(Commentary) (protein specific)
Commentary
Organism
His-tagged subunits Pdx1 and Pdx2 expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL
Plasmodium berghei
His-tagged subunits Pdx1 and Pdx2 expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL
Plasmodium falciparum
Crystallization (Commentary) (protein specific)
Crystallization
Organism
chimeric complex of Pdx2 and Pdx1 from Plasmodium berghei
Plasmodium falciparum
Pdx1, chimeric complex of Pdx1 and Pdx2 from Plasmodium falciparum
Plasmodium berghei
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
H196N
Pdx2, catalytically inactive
Plasmodium falciparum
H199N
Pdx2
Plasmodium berghei
L82A
Pdx1
Plasmodium berghei
M103A
Pdx1
Plasmodium berghei
M103F
Pdx1
Plasmodium berghei
M148L
Pdx1
Plasmodium berghei
M19V
Pdx1
Plasmodium berghei
M46I
Pdx1
Plasmodium berghei
Purification (Commentary) (protein specific)
Commentary
Organism
immobilized metal ion affinity chromatography (Ni2+), gel filtration
Plasmodium berghei
immobilized metal ion affinity chromatography (Ni2+), gel filtration
Plasmodium falciparum
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.00025
-
L82A mutant Pdx1, NH4Cl as NH3+ donor, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.00031
-
M103A mutant Pdx1, NH4Cl as NH3+ donor, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.00042
-
M103A mutant Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0007
-
Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium falciparum
0.0008
-
M148L mutant Pdx1, NH4Cl as NH3+ donor, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0009
-
Pdx1, NH4Cl as NH3+ donor, pyridoxal 5'-phosphate synthesis, pH 8, 37°C; Plasmodium falciparum Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0009
-
Pdx1/Plasmodium berghei Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium falciparum
0.0011
-
Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0012
-
L82A mutant Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0013
-
Pdx1/Plasmodium falciparum Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0013
-
Plasmodium berghei Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium falciparum
0.0015
-
M46I mutant Pdx1, NH4Cl as NH3+ donor, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0018
-
M19V mutant Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.002
-
M19V mutant Pdx1, NH4Cl as NH3+ donor, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0028
-
M46I mutant Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.0037
-
M148L mutant Pdx1/Pdx2 complex, pyridoxal 5'-phosphate synthesis, pH 8, 37°C
Plasmodium berghei
0.087
-
M19V mutant Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
0.115
-
L82A mutant Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
0.126
-
M103F mutant Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
0.15
-
Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
0.175
-
Plasmodium falciparum Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
0.175
-
Pdx1/Plasmodium berghei Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium falciparum
0.178
-
M103A mutant Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
0.229
-
M148L mutant Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
0.233
-
Pdx1/Plasmodium falciparum Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
0.233
-
Plasmodium berghei Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium falciparum
0.26
-
Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium falciparum
0.284
-
M46I mutant Pdx1/Pdx2 complex, glutaminase activity, pH 8, 30°C
Plasmodium berghei
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-ribose 5-phosphate + glyceraldehyde 3-phosphate + L-glutamine
-
726499
Plasmodium falciparum
pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate
-
-
-
?
D-ribose 5-phosphate + glyceraldehyde 3-phosphate + L-glutamine
-
726499
Plasmodium berghei
pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate
-
-
-
?
D-ribose 5-phosphate + glyceraldehyde 3-phosphate + NH4+
in the absence of Pdx2
726499
Plasmodium falciparum
pyridoxal 5'-phosphate + 4 H2O + phosphate
-
-
-
?
D-ribose 5-phosphate + glyceraldehyde 3-phosphate + NH4+
in the absence of Pdx2
726499
Plasmodium berghei
pyridoxal 5'-phosphate + 4 H2O + phosphate
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
homododecamer
Pdx1, random association pattern of up to 12 Pdx2 subunits to the Pdx1 dodecamer
Plasmodium berghei
homododecamer
Pdx1, random association pattern of up to 12 Pdx2 subunits to the Pdx1 dodecamer
Plasmodium falciparum
Other publictions for EC 4.3.3.6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
748203
Smith
Crystal structures capture th ...
Geobacillus kaustophilus
J. Biol. Chem.
290
5226-5239
2015
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1
1
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3
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1
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2
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1
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1
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3
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3
1
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3
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730418
Belitsky
Role of PdxR in the activation ...
Listeria monocytogenes
Mol. Microbiol.
92
1113-1128
2014
1
-
1
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1
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724239
Reeksting
Exploring inhibition of Pdx1, ...
Plasmodium falciparum
Biochem. J.
449
175-187
2013
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-
1
-
5
-
5
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3
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1
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1
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1
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1
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729134
Kim
Crystal structure of Mycobacte ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Biochem. Biophys. Res. Commun.
435
255-259
2013
-
1
1
1
1
-
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1
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3
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1
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1
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1
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4
4
-
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-
729433
Itagaki
Differences in the roles of a ...
Bacillus circulans, Bacillus circulans SANK 72073, Bacillus subtilis
Biosci. Biotechnol. Biochem.
77
1481-1485
2013
-
-
2
-
1
-
-
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3
-
5
-
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3
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1
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3
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2
2
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-
721233
Yoon
Overexpression, crystallizatio ...
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Acta Crystallogr. Sect. F
68
440-442
2012
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1
1
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2
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9
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1
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723192
Matsuura
Crystal structure of pyridoxal ...
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Mol. Cells
34
407-412
2012
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1
1
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5
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1
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2
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726499
Guedez
Assembly of the eukaryotic PLP ...
Plasmodium berghei, Plasmodium falciparum
Structure
20
172-184
2012
-
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2
2
8
-
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4
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2
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28
-
4
2
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8
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28
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4
2
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716150
Jochmann
Positive transcriptional contr ...
Corynebacterium glutamicum, Corynebacterium glutamicum NJ0898
Microbiology
157
77-88
2011
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2
1
1
2
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726269
Moccand
It takes two to Tango: Definin ...
Bacillus subtilis
PLoS ONE
6
e16042
2011
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1
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8
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24
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1
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1
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1
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1
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13
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8
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24
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1
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13
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25
25
724219
Zhang
Structural insights into the c ...
Saccharomyces cerevisiae
Biochem. J.
432
445-450
2010
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1
1
6
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6
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724999
Derrer
Defining the structural requir ...
Plasmodium falciparum
FEBS Lett.
584
4169-4174
2010
-
-
1
-
7
-
-
-
-
-
2
-
-
1
-
-
1
-
-
-
2
-
2
1
-
-
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-
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-
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-
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1
-
-
7
-
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2
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1
-
-
2
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714170
Wallner
Dissection of contributions fr ...
Bacillus subtilis
Biochemistry
48
1928-1935
2009
-
-
1
-
10
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
1
-
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-
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1
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-
10
-
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-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
713758
Hanes
Trapping of a chromophoric int ...
Bacillus subtilis
Angew. Chem. Int. Ed. Engl.
47
2102-2105
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
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1
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
716306
Hanes
13C NMR snapshots of the compl ...
Bacillus subtilis
Nat. Chem. Biol.
4
425-430
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
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2
-
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1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
715491
Raschle
Reaction mechanism of pyridoxa ...
Bacillus subtilis
J. Biol. Chem.
282
6098-6105
2007
-
-
-
-
5
-
-
2
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
1
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
4
1
-
-
-
-
-
-
-
2
2
716736
Strohmeier
Structure of a bacterial pyrid ...
Bacillus subtilis
Proc. Natl. Acad. Sci. USA
103
19284-19289
2006
-
-
1
1
-
-
-
-
-
-
-
-
-
5
-
-
1
-
-
-
-
-
-
1
1
-
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-
-
-
-
-
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-
-
1
-
1
-
-
-
-
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1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
715247
Burns
Reconstitution and biochemical ...
Bacillus subtilis
J. Am. Chem. Soc.
127
3682-3683
2005
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
715478
Raschle
On the two components of pyrid ...
Bacillus subtilis
J. Biol. Chem.
280
32291-32300
2005
-
-
1
-
-
-
1
3
-
1
-
1
-
1
-
-
1
-
-
-
-
-
4
-
1
-
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2
1
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-
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1
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1
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3
-
1
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1
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1
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4
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1
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2
2