Literature summary for 4.3.2.9 extracted from

Dong, J.; Zhou, Y.; Liao, Z.; Huang, Q.; Feng, S.; Li, Y.
Role of gamma-glutamyl cyclotransferase as a therapeutic target for colorectal cancer based on the lentivirus-mediated system (2016), Anticancer Drugs, 27, 1011-1020 .

Search for more literature for 4.3.2.9

Application

Application	Comment	Organism
medicine	GGCT silencing significantly suppresses proliferation of colorectal cancer cells and arrests cell cycle at the G0/G1 phase by regulating the expression of p21, p27, and cyclin E. GGCT silencing triggers the apoptosis of colorectal cancer cells by activating caspase-3 and cleaved poly-ADPribose polymerase pathways and downregulating the phosphorylation proline-rich Akt substrate of 40 kDa (PRAS40) expression levels. GGCT silencing combined with 5-fluorouracil treatment further induces the apoptotic rate of colorectal cancer cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O75223	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colorectal cancer cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
GGCT	-	Homo sapiens

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Release 2023.1 (January 2023)