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Literature summary for 4.3.2.9 extracted from

  • Schilling, S.; Hoffmann, T.; Manhart, S.; Hoffmann, M.; Demuth, H.U.
    Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions (2004), FEBS Lett., 563, 191-196.
    View publication on PubMed
Search for more literature for 4.3.2.9

Inhibitors

Inhibitors Comment Organism Structure
benzimidazole
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Km-values for Gln-containing peptides Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens N-terminal pyroglutamate formation is a posttranslational event in the processing of bioactive neuropeptides such as thyrotropin-releasing hormone and neurotensin during their maturation in the secretory pathway. The enzyme also catalyzes N-terminal glutamate cyclization ?
-
 ?
additional information Carica papaya N-terminal pyroglutamate formation is a posttranslational event in the processing of bioactive neuropeptides such as thyrotropin-releasing hormone and neurotensin during their maturation in the secretory pathway. The enzyme also catalyzes N-terminal glutamate cyclization ?
-
 ?

Organism

Organism UniProt Comment Textmining
Carica papaya
-
-
-
Homo sapiens
-
 recombinant
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gln-2-naphthylamide
-
 Carica papaya pyroglutamyl-2-naphthylamide + NH3
-
 ?
Gln1-containing peptide
-
 Homo sapiens pyroglutamyl peptide
-
 ?
Glu-2-naphthylamide
-
 Carica papaya ?
-
 ?
additional information N-terminal pyroglutamate formation is a posttranslational event in the processing of bioactive neuropeptides such as thyrotropin-releasing hormone and neurotensin during their maturation in the secretory pathway. The enzyme also catalyzes N-terminal glutamate cyclization Homo sapiens ?
-
 ?
additional information N-terminal pyroglutamate formation is a posttranslational event in the processing of bioactive neuropeptides such as thyrotropin-releasing hormone and neurotensin during their maturation in the secretory pathway. The enzyme also catalyzes N-terminal glutamate cyclization Carica papaya ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 cyclization of Glu Carica papaya
8
-
 cyclization of Gln Carica papaya

pH Range

pH Minimum pH Maximum Comment Organism
5.4 7.5 pH 5.4: about 85% of maximal activity, pH 7.5: about 50% of maximal activity, cyclization of Glu Carica papaya
7 8 pH 7.0: about 60% of maximal activity, pH 8.0: optimum, cyclization of Gln Carica papaya