Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.3.2.7 extracted from

  • Kaur, A.; Gautam, R.; Srivastava, R.; Chandel, A.; Kumar, A.; Karthikeyan, S.; Bachhawat, A.K.
    ChaC2, an enzyme for slow turnover of cytosolic glutathione (2017), J. Biol. Chem., 292, 638-651 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine higher levels of ChaC1 transcripts are present in all the tumorigenic cell lines examined Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
to 1.43 A resolution. The catalytic site is defined by a fortuitous benzoic acid molecule bound to the crystal structure Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3
-
glutathione pH 8..0, 37°C Mus musculus
3.7
-
glutathione pH 8.0, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol constitutively expressed Homo sapiens 5829
-
cytosol constitutively expressed Mus musculus 5829
-
cytosol constitutively expressed Saccharomyces cerevisiae 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21000
-
gel filtration Mus musculus
22000
-
gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione Homo sapiens
-
L-cysteinylglycine + 5-oxo-L-proline
-
?
glutathione Mus musculus
-
L-cysteinylglycine + 5-oxo-L-proline
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8WUX2
-
-
Mus musculus Q9CQG1
-
-
Saccharomyces cerevisiae P32656
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione
-
Homo sapiens L-cysteinylglycine + 5-oxo-L-proline
-
?
glutathione
-
Mus musculus L-cysteinylglycine + 5-oxo-L-proline
-
?
glutathione
-
Saccharomyces cerevisiae L-cysteinylglycine + 5-oxo-L-proline
-
?
additional information no activity against either gamma-glutamyl amino acids or oxidized glutathione Homo sapiens ?
-
?
additional information no activity against either gamma-glutamyl amino acids or oxidized glutathione Mus musculus ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 22000, SDS-PAGE Homo sapiens
monomer 1 * 21000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
CHAC2
-
Homo sapiens
CHAC2
-
Mus musculus
GCG1
-
Saccharomyces cerevisiae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.13
-
glutathione pH 8..0, 37°C Mus musculus
0.27
-
glutathione pH 8.0, 37°C Homo sapiens

General Information

General Information Comment Organism
physiological function isoform ChaC2 degrades glutathione at lower efficiency than its ChaC1 homologue Homo sapiens
physiological function isoform ChaC2 degrades glutathione at lower efficiency than its ChaC1 homologue Mus musculus