Application | Comment | Organism |
---|---|---|
medicine | higher levels of ChaC1 transcripts are present in all the tumorigenic cell lines examined | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
to 1.43 A resolution. The catalytic site is defined by a fortuitous benzoic acid molecule bound to the crystal structure | Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
3 | - |
glutathione | pH 8..0, 37°C | Mus musculus | |
3.7 | - |
glutathione | pH 8.0, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | constitutively expressed | Homo sapiens | 5829 | - |
cytosol | constitutively expressed | Mus musculus | 5829 | - |
cytosol | constitutively expressed | Saccharomyces cerevisiae | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
21000 | - |
gel filtration | Mus musculus |
22000 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione | Homo sapiens | - |
L-cysteinylglycine + 5-oxo-L-proline | - |
? | |
glutathione | Mus musculus | - |
L-cysteinylglycine + 5-oxo-L-proline | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8WUX2 | - |
- |
Mus musculus | Q9CQG1 | - |
- |
Saccharomyces cerevisiae | P32656 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione | - |
Homo sapiens | L-cysteinylglycine + 5-oxo-L-proline | - |
? | |
glutathione | - |
Mus musculus | L-cysteinylglycine + 5-oxo-L-proline | - |
? | |
glutathione | - |
Saccharomyces cerevisiae | L-cysteinylglycine + 5-oxo-L-proline | - |
? | |
additional information | no activity against either gamma-glutamyl amino acids or oxidized glutathione | Homo sapiens | ? | - |
? | |
additional information | no activity against either gamma-glutamyl amino acids or oxidized glutathione | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 22000, SDS-PAGE | Homo sapiens |
monomer | 1 * 21000, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
CHAC2 | - |
Homo sapiens |
CHAC2 | - |
Mus musculus |
GCG1 | - |
Saccharomyces cerevisiae |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.13 | - |
glutathione | pH 8..0, 37°C | Mus musculus | |
0.27 | - |
glutathione | pH 8.0, 37°C | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform ChaC2 degrades glutathione at lower efficiency than its ChaC1 homologue | Homo sapiens |
physiological function | isoform ChaC2 degrades glutathione at lower efficiency than its ChaC1 homologue | Mus musculus |