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Literature summary for 4.3.2.5 extracted from

  • Han, M.; Park, D.; Vanderzalm, P.J.; Mains, R.E.; Eipper, B.A.; Taghert, P.H.
    Drosophila uses two distinct neuropeptide amidating enzymes, dPAL1 and dPAL2 (2004), J. Neurochem., 90, 129-141.
    View publication on PubMed
Search for more literature for 4.3.2.5

Activating Compound

Activating Compound Comment Organism Structure
Cd2+
-
 Drosophila melanogaster
Cd2+
-
 Rattus norvegicus
Co2+
-
 Drosophila melanogaster
Co2+
-
 Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
-
 Drosophila melanogaster
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
EDTA 1 mM; 1 mM Drosophila melanogaster

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.013
-
 alpha-N-Acetyl-Tyr-Val-alpha-hydroxyglycine
-
 Rattus norvegicus
0.045
-
 alpha-N-Acetyl-Tyr-Val-alpha-hydroxyglycine
-
 Drosophila melanogaster
0.238
-
 alpha-N-Acetyl-Tyr-Val-alpha-hydroxyglycine
-
 Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Drosophila melanogaster 5783
-
Golgi trans face
-
 Drosophila melanogaster
-
-
soluble
-
 Drosophila melanogaster
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ activates the enzyme Drosophila melanogaster
Cd2+ activates the enzyme Rattus norvegicus
Co2+ activates the enzyme Drosophila melanogaster
Co2+ activates the enzyme Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43900
-
 monomer, secreted, rhodopsin-tagged protein, calculated from amino acid sequence Drosophila melanogaster
44400
-
 monomer, secreted, rhodopsin-tagged protein, calculated from amino acid sequence Drosophila melanogaster
49300
-
 x * 49300, rhodopsin-tagged protein, SDS-PAGE Drosophila melanogaster
51300
-
 x * 51300, rhodopsin-tagged protein, SDS-PAGE Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptidylamidoglycolate Drosophila melanogaster
-
 peptidyl amide + glyoxylate
-
 ?
peptidylamidoglycolate Rattus norvegicus
-
 peptidyl amide + glyoxylate
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9V5E1
-
-
Drosophila melanogaster Q9W1L5
-
-
Rattus norvegicus P14925
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Drosophila melanogaster
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
central nervous system
-
 Drosophila melanogaster
-
central nervous system
-
 Rattus norvegicus
-
neuron
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-N-acetyl-Tyr-Val-alpha-hydroxyglycine
-
 Drosophila melanogaster alpha-N-acetyl-Tyr-Val-NH2 + glyoxylate
-
 ?
alpha-N-acetyl-Tyr-Val-alpha-hydroxyglycine
-
 Rattus norvegicus alpha-N-acetyl-Tyr-Val-NH2 + glyoxylate
-
 ?
peptidylamidoglycolate
-
 Drosophila melanogaster peptidyl amide + glyoxylate
-
 ?
peptidylamidoglycolate
-
 Rattus norvegicus peptidyl amide + glyoxylate
-
 ?

Subunits

Subunits Comment Organism
? x * 49300, rhodopsin-tagged protein, SDS-PAGE Drosophila melanogaster
? x * 51300, rhodopsin-tagged protein, SDS-PAGE Drosophila melanogaster

Synonyms

Synonyms Comment Organism
dPAL1 gene product
-
 Drosophila melanogaster
dPAL2 gene product
-
 Drosophila melanogaster
PAL
-
 Drosophila melanogaster
PAL
-
 Rattus norvegicus
peptidyl-alpha-hydroxyglycine alpha-amidating lyase
-
 Drosophila melanogaster
peptidyl-alpha-hydroxyglycine alpha-amidating lyase
-
 Rattus norvegicus
rPAL gene product
-
 Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
 Drosophila melanogaster
7.5
-
-
 Drosophila melanogaster