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Literature summary for 4.3.2.3 extracted from

  • Percudani, R.; Carnevali, D.; Puggioni, V.
    Ureidoglycolate hydrolase, amidohydrolase, lyase: how errors in biological databases are incorporated in scientific papers and vice versa (2013), Database (Oxford), 2013, bat071.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.3.2.3

Cloned(Commentary)

Cloned (Comment) Organism
gene allA, encoded in the ALL locus Escherichia coli
gene DAL3, the DAL metabolic gene cluster, the so called degradation of allantoin locus, is located on chromosome IX Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
EDTA complete inhibition, the activity can only be rescued by an excess of Ni2+ ions, not by other metal ions, i.e. Ca2+, Co2+, Cu2+, Mg2+, Mn2+, Zn2+, and Fe2+ Escherichia coli
EDTA complete inhibition Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Ni2+ nickel-dependent urea-release activity Escherichia coli
Ni2+ nickel-dependent urea-release activity Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-ureidoglycolate Escherichia coli nickel-dependent urea-release activity glyoxylate + urea
-
 ?
(S)-ureidoglycolate Saccharomyces cerevisiae nickel-dependent urea-release activity glyoxylate + urea
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P63486 gene allA
-
Saccharomyces cerevisiae P32459 gene dal3
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-ureidoglycolate nickel-dependent urea-release activity Escherichia coli glyoxylate + urea
-
 ?
(S)-ureidoglycolate nickel-dependent urea-release activity Saccharomyces cerevisiae glyoxylate + urea
-
 ?
additional information recombinant enzyme from Escherichia coli is unable to release ammonia directly from ureidoglycolate Escherichia coli ?
-
 ?

Synonyms

Synonyms Comment Organism
allA
-
 Escherichia coli
DAL3
-
 Saccharomyces cerevisiae
ureidoglycolate lyase, releasing urea
-
 Escherichia coli
ureidoglycolate lyase, releasing urea
-
 Saccharomyces cerevisiae
YIR032C UniProt Saccharomyces cerevisiae

Expression

Organism Comment Expression
Escherichia coli the locus encoding the enzyme is expressed under anaerobiosis and nitrogen starvation up

General Information

General Information Comment Organism
malfunction DAL3 deletion abolishes the activity on ureidoglycolate Saccharomyces cerevisiae
additional information the AllA structure reveals two gracious small barrel (cupin) folds Escherichia coli