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Literature summary for 4.3.2.2 extracted from

  • Gooding, J.R.; Jensen, M.V.; Dai, X.; Wenner, B.R.; Lu, D.; Arumugam, R.; Ferdaoussi, M.; MacDonald, P.E.; Newgard, C.B.
    Adenylosuccinate is an insulin secretagogue derived from glucose-induced purine metabolism (2015), Cell Rep., 13, 157-167 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.3.2.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate Rattus norvegicus
-
 fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?
N6-(1,2-dicarboxyethyl)AMP Rattus norvegicus
-
 fumarate + AMP
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus D3ZW08
-
-

Source Tissue

Source Tissue Comment Organism Textmining
INS-1 823/13 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 Rattus norvegicus fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?
N6-(1,2-dicarboxyethyl)AMP
-
 Rattus norvegicus fumarate + AMP
-
 ?

Synonyms

Synonyms Comment Organism
ADSL
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus pharmacologic or molecular inhibition of adenylosuccinate synthase expression impairs glucose-stimulated insulin secretion from islet beta-cells down

General Information

General Information Comment Organism
malfunction knockdown of adenylosuccinate lyase causes small increases in AMP, ADP and ATP levels. It does not result in decreases in other adenine nucleotides Rattus norvegicus
metabolism glucose-induced flux through de novo purine synthesis and adenylosuccinate synthase 2 drive increases in adenylosuccinate levels in beta-cells, causing enhanced insulin granule exocytosis Rattus norvegicus
metabolism the enzyme plays two important roles in nucleotide metabolism, serving first to catalyze a proximal step in the purine biosynthetic pathway, the conversion of SAICAR to AICAR (ZMP), and then also acting to degrade S-AMP to AMP and fumarate more distally Rattus norvegicus