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Literature summary for 4.3.2.2 extracted from
- Inhibition of adenylosuccinase by adenylophosphonopropionate and related compounds (1978), Biochemistry, 17, 1365-1370.
General Stability
| General Stability | Organism |
|---|---|
| three cycles of freezing and thawing remove nearly all enzyme activity | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenosine phosphonobutyric, 2'(3'), 5'-diposphate | - |
Rattus norvegicus |  |
| adenyloethylphosphonate | - |
Rattus norvegicus | |
| DL-3-phosphonoalanine | - |
Rattus norvegicus | |
| L-Asp | - |
Rattus norvegicus | |
| mercaptopurinosuccinate | substrate inhibition | Rattus norvegicus | |
| N6-(2-carboxyethyl)-AMP | i.e. adenylopropionate | Rattus norvegicus | |
| N6-(D-1,2-dicarboxyethyl)-AMP | i.e. D-adenylosuccinate | Rattus norvegicus | |
| N6-(DL-1,2-dicarboxy-threo-2-hydroxyethyl)-AMP | i.e. adenylomalate | Rattus norvegicus | |
| N6-(DL-1-carboxy-2-phosphonoethyl)AMP | i.e. adenylophosphonopropionate | Rattus norvegicus | |
| N6-(L-1,3-dicarboxyprop-1-yl)-AMP | i.e. adenyloglutarate | Rattus norvegicus | |
| N6-(L-1-carboxy-2-cyanoethyl)-AMP | i.e. adenylocyanopropionate | Rattus norvegicus | |
| N6-(L-1-carboxy-2-methylsulfoxyethyl)-AMP | i.e. adenylomethylsulfoxypropionate | Rattus norvegicus | |
| N6-(L-1-carboxy-2-sulfinoethyl)-AMP | i.e. adenylosulfinopropionate | Rattus norvegicus | |
| N6-(L-1-carboxy-2-sulfoethyl)-AMP | i.e. adenylosulfopropionate | Rattus norvegicus | |
| phosphopropionoadenosine | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0081 | - |
4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide | - |
Rattus norvegicus | |
| 0.013 | - |
N6-(1,2-dicarboxyethyl)AMP | - |
Rattus norvegicus | |
| 0.02 | - |
mercaptopurinosuccinate | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| muscle | skeletal muscle | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| mercaptopurinosuccinate | - |
Rattus norvegicus | ? | - |
? | |
| N6-(1,2-dicarboxyethyl)AMP | i.e. adenylosuccinate | Rattus norvegicus | fumarate + AMP | - |
? | |
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Release 2023.1 (January 2023)
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