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Literature summary for 4.3.2.2 extracted from

  • Spector, T.; Jones, T.E.; Elion, G.B.
    Specificity of adenylosuccinate synthetase and adenylosuccinate lyase from Leishmania donovani. Selective amination of an antiprotozoal agent (1979), J. Biol. Chem., 254, 8422-8426.
    View publication on PubMed

General Stability

General Stability Organism
unstable to quick freezing in dry ice/acetone Leishmania donovani

Inhibitors

Inhibitors Comment Organism Structure
2'-deoxy-AMP
-
Leishmania donovani
4-aminopyrazolo[3,4-d]pyrimidine ribose 5'-phosphate
-
Leishmania donovani
8-Aza-AMP
-
Leishmania donovani
AMP competitive Leishmania donovani
arabinosyl-AMP
-
Leishmania donovani
EDTA above 15 mM Leishmania donovani
fumarate noncompetitive Leishmania donovani
MgCl2
-
Leishmania donovani
phosphate competitive Leishmania donovani

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0008
-
2'-deoxy-succino-AMP
-
Leishmania donovani
0.0027
-
arabinosyl-succino-AMP
-
Leishmania donovani
0.0033
-
N6-(1,2-dicarboxyethyl)AMP
-
Leishmania donovani
0.004
-
AMP
-
Leishmania donovani
0.0095
-
8-aza-succino-AMP
-
Leishmania donovani
0.011
-
succino-4-aminopyrazolo[3,4-d]pyrimidine ribose 5'-phosphate
-
Leishmania donovani

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
300000
-
gel filtration Leishmania donovani

Organism

Organism UniProt Comment Textmining
Leishmania donovani
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Leishmania donovani

Source Tissue

Source Tissue Comment Organism Textmining
promastigote
-
Leishmania donovani
-

Storage Stability

Storage Stability Organism
-70°C, unstable to storage Leishmania donovani
2°C or -20°C, stable for two months Leishmania donovani

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxy-succino-AMP
-
Leishmania donovani 2'-deoxy-AMP + fumarate
-
?
8-aza-succino-AMP
-
Leishmania donovani 8-aza-AMP + fumarate
-
?
arabinosyl-succino-AMP
-
Leishmania donovani arabinosyl-AMP + ?
-
?
fumarate + AMP
-
Leishmania donovani N6-(1,2-dicarboxyethyl)AMP
-
r
N6-(1,2-dicarboxyethyl)AMP i.e. adenylosuccinate Leishmania donovani fumarate + AMP
-
r
succino-4-aminopyrazolo[3,4-d]pyrimidine ribose 5'-phosphate
-
Leishmania donovani 4-aminopyrazolo[3,4-d]pyrimidine ribose 5'-phosphate + ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.7 8.7 Tris buffer Leishmania donovani