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Literature summary for 4.3.2.1 extracted from

  • Yu, B.; Thompson, G.D.; Yip, P.; Howell, P.L.; Davidson, A.R.
    Mechanisms for intragenic complementation at the human argininosuccinate lyase locus (2001), Biochemistry, 40, 15581-15590.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli and COS-7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
A398D no activity, 15.55 of wild-type activity if coexpressed with Q286R Homo sapiens
D87G no activity, 35.2% of wild-type activity if coexpressed with Q286R Homo sapiens
M360T no actiivty, 10% of wild-type activity if coexpressed with Q286R Homo sapiens
Q286R 3% of wild-type activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.12
-
N,N'-bis(tert-butoxycarbonyl)-5-[(3-aminopropyl)amino]pentan-1-ol
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(Nomega-L-arginino)succinate Homo sapiens
-
fumarate + L-arginine
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
ASL deficiency results in the autosomal, recessive disorder argininosuccinic aciduria
-

Purification (Commentary)

Purification (Comment) Organism
recombinant ASL Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(Nomega-L-arginino)succinate
-
Homo sapiens fumarate + L-arginine
-
?
(Nomega-L-arginino)succinate
-
Homo sapiens fumarate + L-arginine
-
r
N,N'-bis(tert-butoxycarbonyl)-5-[(3-aminopropyl)amino]pentan-1-ol
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ASL
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
34.5
-
N,N'-bis(tert-butoxycarbonyl)-5-[(3-aminopropyl)amino]pentan-1-ol
-
Homo sapiens