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Literature summary for 4.3.1.B2 extracted from

  • Omi, R.; Mizuguchi, H.; Goto, M.; Miyahara, I.; Hayashi, H.; Kagamiyama, H.; Hirotsu, K.
    Structure of imidazole glycerol phosphate synthase from Thermus thermophilus HB8: open-closed conformational change and ammonia tunneling (2002), J. Biochem., 132, 759-765.
    View publication on PubMed
Search for more literature for 4.3.1.B2

Crystallization (Commentary)

Crystallization (Comment) Organism
crystals are obtained by the hanging-drop vapor diffusion method at 20°C. Within two weeks, the crystals grow to full size (0.3 x 0.3 x 0.2 mm) in the space group P4(3)2(1)2 with unit cell parameters a = b = 82.2, c = 156.2 A. X-ray crystallographic study of the native enzyme at 2.3 A resolution Thermus thermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamine + N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate Thermus thermophilus the enzyme catalyzes a step in the histidine biosynthetic pathway located at the branch point to de novo purine biosynthesis L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
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 ?
L-glutamine + N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate Thermus thermophilus HB8 / ATCC 27634 / DSM 579 the enzyme catalyzes a step in the histidine biosynthetic pathway located at the branch point to de novo purine biosynthesis L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
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 ?

Organism

Organism UniProt Comment Textmining
Thermus thermophilus
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Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamine + N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
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 Thermus thermophilus L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?
L-glutamine + N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate the enzyme catalyzes a step in the histidine biosynthetic pathway located at the branch point to de novo purine biosynthesis Thermus thermophilus L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?
L-glutamine + N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
-
 Thermus thermophilus HB8 / ATCC 27634 / DSM 579 L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?
L-glutamine + N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate the enzyme catalyzes a step in the histidine biosynthetic pathway located at the branch point to de novo purine biosynthesis Thermus thermophilus HB8 / ATCC 27634 / DSM 579 L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the fifth step in the histidine biosynthetic pathway located at the branch point to de novo purine biosynthesis Thermus thermophilus