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Literature summary for 4.3.1.4 extracted from
- Identification of novel immunohistochemical tumor markers for primary hepatocellular carcinoma; clathrin heavy chain and formiminotransferase cyclodeaminase (2008), Hepatology, 48, 519-530.
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | putative biomarker, FTCD is useful to distinguish early hepatocellular carcinoma from benign tumors such as regenerative nodule or focal nodular hyperplasia | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | in tumor tissues compared with adjacent nontumor tissue, mRNA levels and the expression of formiminotransferase cyclodeaminase decreases in tumor | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 58870 | - |
predicted and determined by immunoblot analysis of protein lysates | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | downregulation of FTCD participates in liver carcinogenesis | ? | - |
? |  |
| additional information | Homo sapiens | FTCD is a liver-specific enzyme that controls folic acid metabolism | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O95954 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| carcinoma cell | hepatocellular carcinoma tissue | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | downregulation of FTCD participates in liver carcinogenesis | Homo sapiens | ? | - |
? | |
| additional information | FTCD is a liver-specific enzyme that controls folic acid metabolism | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| formiminotransferase cyclodeaminase | - |
Homo sapiens |
| FTCD | - |
Homo sapiens |
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