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Literature summary for 4.3.1.4 extracted from

  • Uyeda, K.; Rabinowitz, J.C.
    Metabolism of formiminoglycine. Formiminotetrahydrofolate cyclodeaminase (1967), J. Biol. Chem., 242, 24-31.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
10-methyltetrahydrofolate competitive Clostridium cylindrosporum
2-hydroxy-2-deaminotetrahydrofolate competitive Clostridium cylindrosporum
4-amino-4-deoxy-10-methylfolate competitive Clostridium cylindrosporum
4-amino-4-deoxyfolate competitive Clostridium cylindrosporum
4-amino-4-deoxytetrahydrofolate competitive Clostridium cylindrosporum
tetrahydrofolate
-
Clostridium acidi-urici
tetrahydrofolate competitive Clostridium cylindrosporum
tetrahydrofolate
-
Sus scrofa
Zn2+
-
Clostridium cylindrosporum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.029
-
(-)-formiminotetrahydropteroyltri-L-glutamate
-
Clostridium cylindrosporum
0.031
-
(-)-formiminotetrahydrofolate
-
Clostridium cylindrosporum
0.04
-
(-)-formiminotetrahydropteroyl-L-aspartate
-
Clostridium cylindrosporum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38000
-
calculated from Svedberg equation (sedimentation equilibrium?) Clostridium cylindrosporum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-formiminotetrahydrofolate Sus scrofa
-
?
-
?
5-formiminotetrahydrofolate Oryctolagus cuniculus
-
?
-
?
5-formiminotetrahydrofolate Clostridium cylindrosporum
-
?
-
?
5-formiminotetrahydrofolate Clostridium acidi-urici
-
?
-
?

Organism

Organism UniProt Comment Textmining
Clostridium acidi-urici
-
-
-
Clostridium cylindrosporum
-
-
-
Oryctolagus cuniculus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Clostridium cylindrosporum

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa
-
liver
-
Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Sus scrofa
additional information
-
-
Clostridium cylindrosporum

Storage Stability

Storage Stability Organism
-20°C, stable for several months at concentrations of 1 mg/ml Clostridium cylindrosporum
enzyme loses activity after repeated freezing and thawing Clostridium cylindrosporum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(-)-formiminotetrahydrofolate
-
Clostridium cylindrosporum ?
-
?
(-)-formiminotetrahydropteroyl-gamma-L-glutamyl-gamma-L-glutamyl-L-glutamate
-
Clostridium cylindrosporum ?
-
?
(-)-formiminotetrahydropteroyl-L-aspartate
-
Clostridium cylindrosporum ?
-
?
(-/+)-formiminotetrahydropteroate
-
Clostridium cylindrosporum ?
-
?
(-/+)-formiminotetrahydropteroyl-D-glutamate
-
Clostridium cylindrosporum ?
-
?
5-formiminotetrahydrofolate
-
Sus scrofa 5,10-methenyltetrahydrofolate + NH3
-
r
5-formiminotetrahydrofolate
-
Oryctolagus cuniculus 5,10-methenyltetrahydrofolate + NH3
-
r
5-formiminotetrahydrofolate
-
Clostridium acidi-urici 5,10-methenyltetrahydrofolate + NH3
-
?
5-formiminotetrahydrofolate reaction is reversible to small extent at pH 8.2 Clostridium cylindrosporum 5,10-methenyltetrahydrofolate + NH3
-
r
5-formiminotetrahydrofolate
-
Sus scrofa ?
-
?
5-formiminotetrahydrofolate
-
Oryctolagus cuniculus ?
-
?
5-formiminotetrahydrofolate
-
Clostridium cylindrosporum ?
-
?
5-formiminotetrahydrofolate
-
Clostridium acidi-urici ?
-
?

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
25 45 enzyme activity increases in a linear manner, temperature optimum is not determined Clostridium cylindrosporum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
-
Clostridium cylindrosporum

pH Range

pH Minimum pH Maximum Comment Organism
5 8 pH 5: 20% of maximal activity, pH 8: 30% of maximal activity Clostridium cylindrosporum

pH Stability

pH Stability pH Stability Maximum Comment Organism
additional information
-
-
Clostridium cylindrosporum
9.8
-
stable for 2 h at 0°C Clostridium cylindrosporum