Literature summary for 4.3.1.30 extracted from

Ko, Y.; Ruszczycky, M.W.; Choi, S.H.; Liu, H.W.
Mechanistic studies of the radical S-adenosylmethionine enzyme DesII with TDP-D-fucose (2015), Angew. Chem. Int. Ed. Engl., 54, 860-863 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine + reduced acceptor	Streptomyces venezuelae	key reaction in the biosynthesis of TDP-desosamine, which is an essential component of many macrolide antibiotics	dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine + acceptor	-	?

Organism

Organism	UniProt	Comment	Textmining
Streptomyces venezuelae	Q9ZGH1	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine + reduced acceptor	key reaction in the biosynthesis of TDP-desosamine, which is an essential component of many macrolide antibiotics	Streptomyces venezuelae	dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine + acceptor	-	?
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine + reduced acceptor	the radical S-adenosylmethionine enzyme catalyzes the C4-deamination of TDP-4-amino-4,6-dideoxyglucose through a C3 radical intermediate. If the C4 amino group is replaced with a hydroxy group (to give TDP-quinovose), the hydroxy group at C3 is oxidized to a ketone with no C4-dehydration	Streptomyces venezuelae	dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine + acceptor	-	?

Synonyms

Synonyms	Comment	Organism
DesII	-	Streptomyces venezuelae

General Information

General Information	Comment	Organism
metabolism	key reaction in the biosynthesis of TDP-desosamine, which is an essential component of many macrolide antibiotics	Streptomyces venezuelae

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Release 2023.1 (January 2023)