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Literature summary for 4.3.1.3 extracted from

  • Eckhart, L.; Schmidt, M.; Mildner, M.; Mlitz, V.; Abtin, A.; Ballaun, C.; Fischer, H.; Mrass, P.; Tschachler, E.
    Histidase expression in human epidermal keratinocytes: regulation by differentiation status and all-trans retinoic acid (2008), J. Dermatol. Sci., 50, 209-215.
    View publication on PubMed
Search for more literature for 4.3.1.3

Activating Compound

Activating Compound Comment Organism Structure
additional information detection of increased trans-urocanic acid levels in the epidermis of patients with psoriasis and in UV-treated epidermis indicates that epidermal histidase may be subject to regulation by endogenous and exogenous factors Homo sapiens
additional information expression of histidase strongly increases at the mRNA and protein levels during differentiation of primary keratinocytes in vitro Homo sapiens
additional information treatment of keratinocytes with UVA and UVB does not significantly change the expression level of histidase Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
all-trans retinoic acid 1 microM suppresses histidase expression almost completely, levels of histidase mRNA expression in the presence of all-trans retinoic acid are significantly lower on day 2 of post-confluence and at all later time points during keratinocyte differentiation Homo sapiens
interleukin-1alpha treatment of IL-1a reduces histidase expression, the suppressive effect can be reverted by concomitant treatment with interleukin-1alpha receptor antagonist Homo sapiens
TGF-alpha most pronounced effect, leads to almost complete suppression of histidase expression Homo sapiens
TNF-alpha suppresses the expression of histidase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-histidine Homo sapiens
-
 trans-urocanic acid + NH3 main ultraviolet light absorption factor of the stratum corneum, component of the natural moisturizing factor (mixture of low-molecular weight, watersoluble substances that maintain the proper hydration of the stratum corneum), trans-urocanic acid is implicated in photoaging of human skin ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis high expression level Homo sapiens
-
keratinocyte epidermal Homo sapiens
-
liver high expression level Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidine
-
 Homo sapiens trans-urocanic acid + NH3 main ultraviolet light absorption factor of the stratum corneum, component of the natural moisturizing factor (mixture of low-molecular weight, watersoluble substances that maintain the proper hydration of the stratum corneum), trans-urocanic acid is implicated in photoaging of human skin ?

Synonyms

Synonyms Comment Organism
histidase
-
 Homo sapiens
histidine ammonia lyase
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
 the activity optimum of histidase near pH 7 suggests that histidase is active predominantly in the lower, less acidic portion of the stratum corneum Homo sapiens