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Literature summary for 4.3.1.3 extracted from
- The enzymic elimination of ammonia (1972), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 7, 75-166.
No PubMed abstract available
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Rattus norvegicus | |
| additional information | - |
additional information | - |
Pseudomonas fluorescens | |
| additional information | - |
additional information | - |
Pseudomonas sp. |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 54000 | - |
4 * 54000, sedimentation in the presence of 6 M guanidine hypochloride and mercaptoethanol | Comamonas testosteroni |
| 189000 | - |
sucrose density gradient centrifugation | Pseudomonas fluorescens |
| 200000 | - |
sedimentation equilibrium | Comamonas testosteroni |
| 204000 | - |
sucrose density gradient centrifugation | toad |
| 210000 | - |
- |
Pseudomonas sp. |
| 210000 | - |
sucrose density gradient centrifugation | Pseudomonas aeruginosa |
| 218000 | - |
sucrose density gradient centrifugation | Pseudomonas fluorescens |
| 220000 | - |
sucrose density gradient centrifugation | Bacillus subtilis |
| 226000 | - |
sucrose density gradient centrifugation | Rattus norvegicus |
| 243000 | - |
sucrose density gradient centrifugation | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | - |
? | - |
? |  |
| additional information | Pseudomonas fluorescens | - |
? | - |
? | |
| additional information | Homo sapiens | deficiency of enzyme results in histidinemia | ? | - |
? | |
| additional information | Pseudomonas fluorescens A.3.12 | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
| Comamonas testosteroni | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Klebsiella aerogenes | - |
- |
- |
| Pseudomonas aeruginosa | - |
- |
- |
| Pseudomonas fluorescens | - |
mutant from ATCC 11250 | - |
| Pseudomonas fluorescens | - |
A.3.12 | - |
| Pseudomonas fluorescens A.3.12 | - |
A.3.12 | - |
| Pseudomonas sp. | - |
ATCC 112996 | - |
| Pseudomonas sp. | - |
ATCC 11,299b | - |
| Rattus norvegicus | - |
- |
- |
| Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
| toad | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| L-histidine = urocanate + NH3 | mechanism | Salmonella enterica subsp. enterica serovar Typhimurium | |
| L-histidine = urocanate + NH3 | mechanism | Bacillus subtilis | |
| L-histidine = urocanate + NH3 | mechanism | Homo sapiens | |
| L-histidine = urocanate + NH3 | mechanism | Rattus norvegicus | |
| L-histidine = urocanate + NH3 | mechanism | Pseudomonas fluorescens | |
| L-histidine = urocanate + NH3 | mechanism | Klebsiella aerogenes | |
| L-histidine = urocanate + NH3 | mechanism | Pseudomonas aeruginosa | |
| L-histidine = urocanate + NH3 | mechanism | Pseudomonas sp. | |
| L-histidine = urocanate + NH3 | mechanism | Comamonas testosteroni | |
| L-histidine = urocanate + NH3 | mechanism | toad |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
toad | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Bacillus subtilis |
| additional information | - |
- |
Rattus norvegicus |
| additional information | - |
- |
Pseudomonas fluorescens |
| additional information | - |
- |
Pseudomonas sp. |
| 3.4 | - |
37°C, pH 9.0, 3.3 mM L-histidine | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-histidine | natural substrate | Salmonella enterica subsp. enterica serovar Typhimurium | urocanate + NH3 | - |
? | |
| L-histidine | natural substrate | Bacillus subtilis | urocanate + NH3 | - |
? | |
| L-histidine | natural substrate | Homo sapiens | urocanate + NH3 | - |
? | |
| L-histidine | natural substrate | Rattus norvegicus | urocanate + NH3 | - |
? | |
| L-histidine | natural substrate | Pseudomonas fluorescens | urocanate + NH3 | - |
? | |
| L-histidine | natural substrate | Klebsiella aerogenes | urocanate + NH3 | - |
? | |
| L-histidine | natural substrate | Pseudomonas aeruginosa | urocanate + NH3 | - |
? | |
| L-histidine | natural substrate | Pseudomonas sp. | urocanate + NH3 | - |
? | |
| L-histidine | natural substrate | Comamonas testosteroni | urocanate + NH3 | - |
? | |
| L-histidine | natural substrate | toad | urocanate + NH3 | - |
? | |
| L-histidine | natural substrate | Pseudomonas fluorescens A.3.12 | urocanate + NH3 | - |
? | |
| additional information | - |
Rattus norvegicus | ? | - |
? | |
| additional information | - |
Pseudomonas fluorescens | ? | - |
? | |
| additional information | deficiency of enzyme results in histidinemia | Homo sapiens | ? | - |
? | |
| additional information | - |
Pseudomonas fluorescens A.3.12 | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | - |
Bacillus subtilis |
| tetramer | - |
Pseudomonas sp. |
| tetramer | 4 * 54000, sedimentation in the presence of 6 M guanidine hypochloride and mercaptoethanol | Comamonas testosteroni |
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