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Literature summary for 4.3.1.3 extracted from

  • Allen, R.L.; Hopewell, R.; Prottey, C.
    Histidine ammonia-lyase in guinea-pig liver and epidermis (1983), Biochem. Soc. Trans., 11, 349-350.
No PubMed abstract available
Search for more literature for 4.3.1.3

Activating Compound

Activating Compound Comment Organism Structure
GSH increases at concentrations below 5 mM, pH 7.4 Cavia porcellus

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoic acid)
-
 Cavia porcellus
dithiothreitol 20 mM, liver and epidermal enzyme, restored by addition with Zn2+ Cavia porcellus
EDTA 0.04 mM, liver and epidermal enzyme, restored by incubation with Zn2+ Cavia porcellus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.36
-
 L-histidine pH 9.2 and pH 7.0, epidermal enzyme Cavia porcellus
0.55
-
 L-histidine pH 9.2, liver enzyme Cavia porcellus
1
-
 L-histidine pH 7.0, liver enzyme Cavia porcellus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
 Cavia porcellus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
220000
-
 gel-permeation chromatography, liver and epidermis enzyme Cavia porcellus

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis isoenzyme Cavia porcellus
-
epidermis stratum granulosum Cavia porcellus
-
epidermis stratum corneum Cavia porcellus
-
liver isoenzyme Cavia porcellus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidine natural substrate Cavia porcellus urocanate + NH3
-
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