Literature summary for 4.3.1.3 extracted from

Klee, C.B.
Stereospecific irreversible inhibition of histidine ammonia-lyase by L-cysteine (1974), Biochemistry, 13, 4501-4507.

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Inhibitors

Inhibitors	Comment	Organism	Structure
D-cysteine	in the presence of Cd2+	Pseudomonas sp.
L-cysteine	competitive in the presence of EDTA; in the presence of Cd2+; irreversible in the presence of O2	Pseudomonas sp.
L-homocysteine	irreversible in the presence of O2 and high pH	Pseudomonas sp.
additional information	-	Pseudomonas sp.

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas sp.	-	ATCC 11,299b	-

Oxidation Stability

Oxidation Stability	Organism
in the absence of L-cysteine enzyme is completely stable in an atmosphere of N2 and O2	Pseudomonas sp.
inactivation of the enzyme by L-cysteine requires presence of O2	Pseudomonas sp.

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Pseudomonas sp.

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-histidine	natural substrate	Pseudomonas sp.	urocanate + NH3	-	?

pH Range

pH Minimum	pH Maximum	Comment	Organism
additional information	-	-	Pseudomonas sp.

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Release 2023.1 (January 2023)