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Literature summary for 4.3.1.24 extracted from

  • Gloge, A.; Zon, J.; Kovari, A.; Poppe, L.; Retey, J.
    Phenylalanine ammonia-lyase: the use of its broad substrate specificity for mechanistic investigations and biocatalysis--synthesis of L-arylalanines (2000), Chem. Eur. J., 6, 3386-3390.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Petroselinum crispum

Inhibitors

Inhibitors Comment Organism Structure
beta-(2-pyrimidinyl)-D,L-alanine competitive inhibition Petroselinum crispum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
4-fluoro-L-phenylalanine
-
Petroselinum crispum
0.033
-
L-phenylalanine
-
Petroselinum crispum
0.045
-
4-chloro-L-phenylalanine
-
Petroselinum crispum
0.05
-
2-chloro-L-phenylalanine
-
Petroselinum crispum
0.065
-
2-fluoro-L-phenylalanine
-
Petroselinum crispum
0.076
-
2,3,4,5,6-pentafluoro-L-phenylalanine
-
Petroselinum crispum
0.079
-
3-fluoro-L-phenylalanine
-
Petroselinum crispum
0.085
-
2,6-difluoro-L-phenylalanine
-
Petroselinum crispum
0.094
-
3-chloro-L-phenylalanine
-
Petroselinum crispum
0.159
-
3,5-difluoro-L-phenylalanine
-
Petroselinum crispum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-phenylalanine Petroselinum crispum
-
(E)-cinnamate + NH3
-
r

Organism

Organism UniProt Comment Textmining
Petroselinum crispum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant PAL Petroselinum crispum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3,4,5,6-pentafluoro-L-phenylalanine
-
Petroselinum crispum 2,3,4,5,6-pentafluoro-trans-cinnamate + NH3
-
r
2,6-difluoro-L-phenylalanine
-
Petroselinum crispum 2,6-difluoro-trans-cinnamate + NH3
-
r
2-chloro-L-phenylalanine
-
Petroselinum crispum 2-chloro-trans-cinnamate + NH3
-
r
2-fluoro-L-phenylalanine
-
Petroselinum crispum 2-fluoro-trans-cinnamate + NH3
-
r
3,5-difluoro-L-phenylalanine
-
Petroselinum crispum 3,5-difluoro-trans-cinnamate + NH3
-
r
3-chloro-L-phenylalanine
-
Petroselinum crispum 3-chloro-trans-cinnamate + NH3
-
r
3-fluoro-L-phenylalanine
-
Petroselinum crispum 3-fluoro-trans-cinnamate + NH3
-
r
4-chloro-L-phenylalanine
-
Petroselinum crispum 4-chloro-trans-cinnamate + NH3
-
?
4-fluoro-L-phenylalanine
-
Petroselinum crispum 4-fluoro-trans-cinnamate + NH3
-
r
beta-(5-pyrimidinyl)-D,L-alanine
-
Petroselinum crispum ?
-
?
L-phenylalanine
-
Petroselinum crispum (E)-cinnamate + NH3
-
r
L-phenylalanine reaction can be reversed by applying high concentrations of ammonia Petroselinum crispum (E)-cinnamate + NH3
-
?

Synonyms

Synonyms Comment Organism
PAL
-
Petroselinum crispum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
7
-
beta-(2-pyrimidinyl)-D,L-alanine
-
Petroselinum crispum