Literature summary for 4.3.1.18 extracted from

Federiuk, C.S.; Bayer, R.; Shafer, J.A.
Characterization of the catalytic pathway for D-serine dehydratase (1983), J. Biol. Chem., 258, 5379-5385.

Search for more literature for 4.3.1.18

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.083	-	D-Thr	pH 5.7, 25°C	Escherichia coli
0.086	-	D-Ser	pH 5.7, 25°C	Escherichia coli
0.24	-	D-Ser	pH 7.8, 5°C	Escherichia coli
0.35	-	D-Ser	pH 7.8, 25°C	Escherichia coli
0.68	-	D-Thr	pH 7.8, 25°C	Escherichia coli
1.1	-	D-allothreonine	pH 5.7, 25°C	Escherichia coli
1.68	-	D-Ser	pH 8.9, 25°C	Escherichia coli
2.4	-	D-allothreonine	pH 7.8, 25°C	Escherichia coli
4	-	L-Ser	pH 7.8, 25°C	Escherichia coli
4.9	-	D-allothreonine	pH 8.9, 25°C	Escherichia coli
11	-	L-Ser	pH 5.8, 25°C	Escherichia coli
12.3	-	L-Ser	pH 8.9, 25°C	Escherichia coli
16	-	D-Thr	pH 8.9, 25°C	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-Allothreonine	-	Escherichia coli	?	-	?
D-serine	-	Escherichia coli	pyruvate + NH3	-	?
D-threonine	-	Escherichia coli	2-oxobutanoate + NH3	-	?
L-allothreonine	-	Escherichia coli	?	-	?
L-serine	very low activity	Escherichia coli	pyruvate + NH3	-	?
L-Thr	-	Escherichia coli	?	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.112	-	D-allothreonine	pH 5.7, 25°C	Escherichia coli
0.12	-	L-Ser	pH 5.8, 25°C	Escherichia coli
0.14	-	L-Ser	pH 8.9, 25°C	Escherichia coli
0.153	-	L-Ser	pH 7.8, 25°C	Escherichia coli
0.92	-	D-allothreonine	pH 8.9, 25°C	Escherichia coli
0.95	-	D-Thr	pH 5.8, 25°C	Escherichia coli
1.8	-	L-allothreonine	pH 7.8, 25°C	Escherichia coli
9.4	-	D-Ser	pH 5.7, 25°C	Escherichia coli
17.2	-	L-Thr	pH 8.9, 25°C	Escherichia coli
19.6	-	L-Thr	pH 7.8, 25°C	Escherichia coli
30	-	D-Ser	pH 7.8, 5°C	Escherichia coli
48	-	D-Ser	pH 8.9, 25°C	Escherichia coli
118	-	D-Ser	pH 7.8, 25°C	Escherichia coli

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Release 2023.1 (January 2023)