Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
H152S | ratio of elimination reaction to racemization is 1.4 compared to 3.7 in wild-type | Mus musculus |
N154F | ratio of elimination reaction to racemization is 0.33 compared to 3.7 in wild-type | Mus musculus |
P153S | ratio of elimination reaction to racemization is 0.24 compared to 3.7 in wild-type | Mus musculus |
Q155D | ratio of elimination reaction to racemization is 0.25 compared to 3.7 in wild-type | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
8.5 | - |
D-serine | wild-type, alpha,beta-elimination, pH 7.4, 37°C | Mus musculus | |
9 | - |
L-serine | wild-type, alpha,beta-elimination, pH 7.4, 37°C | Mus musculus | |
9 | - |
D-serine | wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C | Mus musculus | |
10 | - |
L-serine | wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C | Mus musculus | |
11 | - |
L-serine | mutant Q155D, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C | Mus musculus | |
12 | - |
D-serine | mutant Q155D, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C | Mus musculus | |
55 | - |
D-threonine | wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C | Mus musculus | |
60 | - |
D-threonine | mutant Q155D, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
bifunctional enzymes, racemization of serine and alpha,beta-elimination of L-serine | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-serine | alpha,beta-elimination reaction | Mus musculus | pyruvate + NH3 | - |
? | |
D-serine | racemization reaction | Mus musculus | L-serine | - |
r | |
D-threonine | - |
Mus musculus | 2-oxobutyrate + NH3 | - |
? | |
L-serine | alpha,beta-elimination reaction | Mus musculus | pyruvate + NH3 | - |
? | |
L-serine | racemization reaction | Mus musculus | D-serine | - |
r | |
L-threonine | alpha,beta-elimination reaction | Mus musculus | 2-oxobutyrate + NH3 | - |
? | |
additional information | ration of elimination reaction/racemization reaction for substrate L-serine is 3.7 | Mus musculus | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0033 | - |
D-serine | wild-type, pH 7.4, 37°C | Mus musculus | |
0.012 | - |
D-serine | mutant Q155D, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C | Mus musculus | |
0.028 | - |
D-threonine | mutant Q155D, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C | Mus musculus | |
0.033 | - |
L-serine | mutant Q155D, presence of ATP, pH 7.4, 37°C | Mus musculus | |
0.033 | - |
L-serine | wild-type, alpha,beta-elimination, pH 7.4, 37°C | Mus musculus | |
0.042 | - |
D-serine | wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C | Mus musculus | |
0.166 | - |
L-serine | wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C | Mus musculus | |
0.3 | - |
D-threonine | wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C | Mus musculus |