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Literature summary for 4.3.1.17 extracted from
- Bacterial L-serine dehydratases: a new family of enzymes containing iron-sulfur clusters (1993), Trends Biochem. Sci., 18, 297-300.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | required | Clostridium acidi-urici |  |
| Fe2+ | required | Limosilactobacillus fermentum | |
| Fe2+ | requires activation | Escherichia coli | |
| Iron | enzyme contains one [4Fe-4S]cluster per heterodimer | Peptoniphilus asaccharolyticus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 25000 | - |
1 * 25000 + 1 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers | Peptoniphilus asaccharolyticus |
| 25000 | - |
2 * 25000 + 2 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers | Peptoniphilus asaccharolyticus |
| 25000 | - |
3 * 25000 + 3 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers | Peptoniphilus asaccharolyticus |
| 25000 | - |
4 * 25000 + 4 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers | Peptoniphilus asaccharolyticus |
| 30000 | - |
1 * 25000 + 1 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers | Peptoniphilus asaccharolyticus |
| 30000 | - |
2 * 25000 + 2 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers | Peptoniphilus asaccharolyticus |
| 30000 | - |
3 * 25000 + 3 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers | Peptoniphilus asaccharolyticus |
| 30000 | - |
4 * 25000 + 4 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers | Peptoniphilus asaccharolyticus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arthrobacter globiformis | - |
- |
- |
| Burkholderia cepacia | - |
- |
- |
| Clostridium acidi-urici | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Klebsiella aerogenes | - |
- |
- |
| Limosilactobacillus fermentum | - |
- |
- |
| Peptoniphilus asaccharolyticus | - |
- |
- |
Oxidation Stability
| Oxidation Stability | Organism |
|---|---|
| inactivated upon exposure to air, reactivated by Fe2+ under aerobic conditions | Peptoniphilus asaccharolyticus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-serine | - |
Escherichia coli | pyruvate + NH3 | - |
? | |
| L-serine | - |
Klebsiella aerogenes | pyruvate + NH3 | - |
? | |
| L-serine | - |
Clostridium acidi-urici | pyruvate + NH3 | - |
? | |
| L-serine | - |
Peptoniphilus asaccharolyticus | pyruvate + NH3 | - |
? | |
| L-serine | - |
Arthrobacter globiformis | pyruvate + NH3 | - |
? | |
| L-serine | - |
Limosilactobacillus fermentum | pyruvate + NH3 | - |
? | |
| L-serine | - |
Burkholderia cepacia | pyruvate + NH3 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 1 * 25000 + 1 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers | Peptoniphilus asaccharolyticus |
| hexamer | 3 * 25000 + 3 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers | Peptoniphilus asaccharolyticus |
| octamer | 4 * 25000 + 4 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers | Peptoniphilus asaccharolyticus |
| tetramer | - |
Limosilactobacillus fermentum |
| tetramer | 2 * 25000 + 2 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers | Peptoniphilus asaccharolyticus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | pyridoxal-5'-phosphate-independent enzyme | Klebsiella aerogenes | |
| pyridoxal 5'-phosphate | pyridoxal-5'-phosphate-independent enzyme | Peptoniphilus asaccharolyticus | |
| pyridoxal 5'-phosphate | pyridoxal-5'-phosphate-independent enzyme | Limosilactobacillus fermentum | |
| pyridoxal 5'-phosphate | pyridoxal-5'-phosphate-independent enzyme | Burkholderia cepacia | |
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