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Literature summary for 4.3.1.10 extracted from
- L-Serine O-sulphate-degrading system of rat liver (1971), Methods Enzymol., 17B, 361-367.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | - |
Rattus norvegicus |  |
| D-serine O-sulfate | - |
Rattus norvegicus | |
| DL-homoserine O-sulfate | weak competitive | Rattus norvegicus | |
| Fe2+ | - |
Rattus norvegicus | |
| Hg2+ | - |
Rattus norvegicus | |
| hydroxylamine | - |
Rattus norvegicus | |
| iodoacetic acid | - |
Rattus norvegicus | |
| O-acetyl-L-serine | potent non-competitive | Rattus norvegicus | |
| O-phospho-L-serine | potent non-competitive | Rattus norvegicus | |
| p-chloromercuribenzoate | at a concentration of 0.1 mM, partly reversible with 2-mercaptoethanol | Rattus norvegicus | |
| Pb2+ | - |
Rattus norvegicus | |
| Zn2+ | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 23 | - |
L-serine O-sulfate | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.48 | - |
- |
Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, stable for several weeks | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-chloroalanine | - |
Rattus norvegicus | ? | - |
? | |
| D-serine-O-sulfate | activity: 1/40 that towards L-isomer | Rattus norvegicus | pyruvate + NH3 + SO42- | - |
? | |
| L-serine O-sulfate | - |
Rattus norvegicus | pyruvate + NH3 + sulfate | - |
? | |
| L-seryl-glycine O-sulfate | not very efficient substrate | Rattus norvegicus | ? | - |
? | |
| L-seryl-L-alanine O-sulfate | not very efficient substrate | Rattus norvegicus | ? | - |
? | |
| L-seryl-L-leucine O-sulfate | not very efficient substrate | Rattus norvegicus | ? | - |
? | |
| L-seryl-L-phenylalanine O-sulfate | not very efficient substrate | Rattus norvegicus | ? | - |
? | |
| L-seryl-L-valine O-sulfate | not very efficient substrate | Rattus norvegicus | ? | - |
? | |
| L-threonine O-sulfate | weak activity | Rattus norvegicus | 2-oxobutanoate + NH3 + SO42- | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 38 | - |
enzyme assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
in 0.1 M Tris-HCl | Rattus norvegicus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 8 | stable between | Rattus norvegicus |
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Release 2023.1 (January 2023)
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