Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hippocampus | hippocampal neuron | Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA | - |
Rattus norvegicus | fragments of DNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
APE1 | - |
Rattus norvegicus |
apurinic/apyrimidinic endonuclease | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | pituitary adenylate cyclase-activating polypeptide induces expression of APE1 in hippocampal neurons, induction of APE1 expression requires PKA and p38-dependent phosphorylation of cAMP response-element binding and activating transcription factor 2, which leads to transactivation of the APE1 promoter | up |
General Information | Comment | Organism |
---|---|---|
malfunction | APE1 knockdown abrogates neuroprotection against cerebral ischemia | Rattus norvegicus |
physiological function | APE1 is required for pituitary adenylate cyclase-activating polypeptide-induced neuroprotection against global cerebral ischemia | Rattus norvegicus |