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Literature summary for 4.2.99.18 extracted from

  • Stetler, R.A.; Gao, Y.; Zukin, R.S.; Vosler, P.S.; Zhang, L.; Zhang, F.; Cao, G.; Bennett, M.V.; Chen, J.
    Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia (2010), Proc. Natl. Acad. Sci. USA, 107, 3204-3209.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
hippocampus hippocampal neuron Rattus norvegicus
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neuron
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
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Rattus norvegicus fragments of DNA
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?

Synonyms

Synonyms Comment Organism
APE1
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Rattus norvegicus
apurinic/apyrimidinic endonuclease
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Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus pituitary adenylate cyclase-activating polypeptide induces expression of APE1 in hippocampal neurons, induction of APE1 expression requires PKA and p38-dependent phosphorylation of cAMP response-element binding and activating transcription factor 2, which leads to transactivation of the APE1 promoter up

General Information

General Information Comment Organism
malfunction APE1 knockdown abrogates neuroprotection against cerebral ischemia Rattus norvegicus
physiological function APE1 is required for pituitary adenylate cyclase-activating polypeptide-induced neuroprotection against global cerebral ischemia Rattus norvegicus