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Literature summary for 4.2.99.18 extracted from

  • Chattopadhyay, R.; Bhattacharyya, A.; Crowe, S.E.
    Dual regulation by apurinic/apyrimidinic endonuclease-1 inhibits gastric epithelial cell apoptosis during Helicobacter pylori infection (2010), Cancer Res., 70, 2799-2808.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AGS cell
-
Homo sapiens
-
gastric epithelial cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
Homo sapiens fragments of DNA
-
?

Synonyms

Synonyms Comment Organism
APE-1
-
Homo sapiens
apurinic/apyrimidinic endonuclease-1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens Helicobacter pylori infection induces apoptosis and increases APE-1 expression in human gastric epithelial cells up

General Information

General Information Comment Organism
malfunction short hairpin RNA-mediated stable suppression of APE-1 results in increased apoptosis in gastric epithelial cells after Helicobacter pylori infection Homo sapiens
physiological function both DNA repair and acetylation functions of APE-1 modulate programmed cell death, the DNA repair activity of APE-1 inhibits the mitochondrial pathway, whereas the acetylation function inhibits the extrinsic pathway during Helicobacter pylori infection Homo sapiens