Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
36000 | - |
SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
AGS cell | - |
Homo sapiens | - |
gastric epithelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA | - |
Homo sapiens | fragments of DNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
APE-1 | - |
Homo sapiens |
apurinic/apyrimidinic endonuclease-1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | Helicobacter pylori infection induces apoptosis and increases APE-1 expression in human gastric epithelial cells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | short hairpin RNA-mediated stable suppression of APE-1 results in increased apoptosis in gastric epithelial cells after Helicobacter pylori infection | Homo sapiens |
physiological function | both DNA repair and acetylation functions of APE-1 modulate programmed cell death, the DNA repair activity of APE-1 inhibits the mitochondrial pathway, whereas the acetylation function inhibits the extrinsic pathway during Helicobacter pylori infection | Homo sapiens |