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Literature summary for 4.2.99.18 extracted from

  • Bhakat, K.; Mantha, A.; Mitra, S.
    Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein (2009), Antioxid. Redox Signal., 11, 621-637.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
Homo sapiens
-
monocyte
-
Homo sapiens
-
THP-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
Homo sapiens fragments of DNA
-
?

Synonyms

Synonyms Comment Organism
APE1
-
Homo sapiens
apurinic-apyrimidinic endonuclease I
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Homo sapiens

General Information

General Information Comment Organism
malfunction siRNA knockdown of endogenous APE1 impairs high-mobility group box 1-mediated cytokine expression and MAPK activation in THP-1 cells Homo sapiens
physiological function APE1 is a dual regulator of inflammatory signaling to high-mobility group box 1 by human monocytes/macrophages. Forced cytoplasmic overexpression of APE1 profoundly attenuates the upregulation of high-mobility group box 1-mediated reactive oxygen species generation, cytokine secretion, and cyclooxygenase-2 expression by primary monocytes and macrophage-like THP-1 cell lines, the extracellular release of high-mobility group box 1 by activated macrophages is inhibited by APE1 transfection Homo sapiens