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Literature summary for 4.2.99.18 extracted from

  • Lam, W.; Park, S.Y.; Leung, C.H.; Cheng, Y.C.
    Apurinic/apyrimidinic endonuclease-1 protein level is associated with the cytotoxicity of L-configuration deoxycytidine analogs (troxacitabine and beta-L-2,3-dideoxy-2,3-didehydro-5-fluorocytidine) but not D-configuration deoxycytidine analogs (2006), Mol. Pharmacol., 69, 1607-1614.
    View publication on PubMed
Search for more literature for 4.2.99.18

Application

Application Comment Organism
medicine APE-1 exonuclease activity plays an important role in the removal of L-configuration nucleoside analogs from DNA inside the cell and can be a determining factor in the drug resistance of the analogs Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
RKO cell lines are established, that can be induced by doxycycline to overexpress APE-1 wild-type, mutant C65A, mutant E96A or mutant E96Q Homo sapiens

Protein Variants

Protein Variants Comment Organism
C65A redox deficient mutant Homo sapiens
E96A exonuclease deficient mutant Homo sapiens
E96Q exonuclease deficient mutant Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
mitochondrion
-
 Homo sapiens 5739
-
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
RKO cell protein is extracted Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
RKO cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
APE-1
-
 Homo sapiens
apurinic/apyrimidinic endonuclease-1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 AP endonuclease activity assay Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 AP endonuclease activity assay Homo sapiens