Literature summary for 4.2.99.18 extracted from

van der Kemp, P.A.; Charbonnier, J.B.; Audebert, M.; Boiteux, S.
Catalytic and DNA-binding properties of the human Ogg1 DNA N-glycosylase/AP lyase: biochemical exploration of H270, Q315 and F319, three amino acids of the 8-oxoguanine-binding pocket (2004), Nucleic Acids Res., 32, 570-578.

Search for more literature for 4.2.99.18

Protein Variants

Protein Variants	Comment	Organism
F319A	DNA glycosylase activity is reduced 52.6fold, activity towards abasic sites is reduced 1.5fold	Homo sapiens
H270A	DNA glycosylase activity is reduced 50fold, activity towards abasic sites is reduced 2.3fold	Homo sapiens
H270L	DNA glycosylase activity is reduced 71.4fold, activity towards abasic sites is reduced 3.7fold	Homo sapiens
H270R	DNA glycosylase activity is reduced 3.9fold, activity towards abasic sites is nearly identical to wild-type activity	Homo sapiens
Q315A	DNA glycosylase activity is reduced 1.6fold, activity towards abasic sites is increased 1.18fold	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15527	recombinant	-

Purification (Commentary)

Purification (Comment)	Organism
wild-type and mutant enzymes H270A, H270R, H270L, Q315A, F319A	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	hOgg1 protein catalyzes the excision of 8-oxo-7,8-dihydroguanine and the incision of apurinic and apyrimidinic sites in DNA	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
hOgg1 protein	-	Homo sapiens

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Release 2023.1 (January 2023)