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Literature summary for 4.2.99.18 extracted from

  • Beloglazova, N.G.; Kirpota, O.O.; Starostin, K.V.; Ishchenko, A.A.; Yamkovoy, V.I.; Zharkov, D.O.; Douglas, K.T.; Nevinsky, G.A.
    Thermodynamic, kinetic and structural basis for recognition and repair of abasic sites in DNA by apurinic/apyrimidinic endonuclease from human placenta (2004), Nucleic Acids Res., 32, 5134-5146.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.99.18

Inhibitors

Inhibitors Comment Organism Structure
(pA)10
-
 Homo sapiens
(pA)10*d(pT)10
-
 Homo sapiens
(pA)11*d(pT)11
-
 Homo sapiens
(pA)12
-
 Homo sapiens
(pA)16
-
 Homo sapiens
(pA)16*d(pT)16
-
 Homo sapiens
(pA)2
-
 Homo sapiens
(pA)3
-
 Homo sapiens
(pA)4
-
 Homo sapiens
(pA)4*d(pT)4
-
 Homo sapiens
(pA)6
-
 Homo sapiens
(pA)6*d(pT)6
-
 Homo sapiens
(pA)8
-
 Homo sapiens
(pA)8*d(pT)8
-
 Homo sapiens
(pA)9
-
 Homo sapiens
(pC)10
-
 Homo sapiens
(pC)14
-
 Homo sapiens
(pC)2
-
 Homo sapiens
(pC)4
-
 Homo sapiens
(pC)6
-
 Homo sapiens
(pC)8
-
 Homo sapiens
(pU)10
-
 Homo sapiens
(pU)10*(pA)10
-
 Homo sapiens
(pU)11
-
 Homo sapiens
(pU)16
-
 Homo sapiens
(pU)16*(pA)16
-
 Homo sapiens
(pU)4
-
 Homo sapiens
(pU)4*(pA)4
-
 Homo sapiens
(pU)6
-
 Homo sapiens
(pU)6*(pA)6
-
 Homo sapiens
(pU)8
-
 Homo sapiens
(pU)9
-
 Homo sapiens
(pU)9*(pA)9
-
 Homo sapiens
AMP
-
 Homo sapiens
CMP
-
 Homo sapiens
d(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate))
-
 Homo sapiens
d(p(2,3-dihydroxy-5-oxopentyl phosphate))
-
 Homo sapiens
d(pA)10
-
 Homo sapiens
d(pA)10*d(pT)10
-
 Homo sapiens
d(pA)12
-
 Homo sapiens
d(pA)12*d(pT)12
-
 Homo sapiens
d(pA)14
-
 Homo sapiens
d(pA)14*d(pT)14
-
 Homo sapiens
d(pA)16
-
 Homo sapiens
d(pA)16*d(pT)16
-
 Homo sapiens
d(pA)2
-
 Homo sapiens
d(pA)2*d(pT)2
-
 Homo sapiens
d(pA)20*(pT)20
-
 Homo sapiens
d(pA)4
-
 Homo sapiens
d(pA)4*d(pT)4
-
 Homo sapiens
d(pA)6
-
 Homo sapiens
d(pA)6*d(pT)6
-
 Homo sapiens
d(pA)8
-
 Homo sapiens
d(pA)8*d(pT)8
-
 Homo sapiens
d(pC)10
-
 Homo sapiens
d(pC)11
-
 Homo sapiens
d(pC)13
-
 Homo sapiens
d(pC)2
-
 Homo sapiens
d(pC)3
-
 Homo sapiens
d(pC)5
-
 Homo sapiens
d(pC)7
-
 Homo sapiens
d(pC)9
-
 Homo sapiens
d(pG)2
-
 Homo sapiens
d(pG)4
-
 Homo sapiens
d(pG)6
-
 Homo sapiens
d(pG)8
-
 Homo sapiens
d(pT)10
-
 Homo sapiens
d(pT)11
-
 Homo sapiens
d(pT)12
-
 Homo sapiens
d(pT)14
-
 Homo sapiens
d(pT)15
-
 Homo sapiens
d(pT)2
-
 Homo sapiens
d(pT)3
-
 Homo sapiens
d(pT)4
-
 Homo sapiens
d(pT)6
-
 Homo sapiens
d(pT)8
-
 Homo sapiens
dAMP
-
 Homo sapiens
dCMP
-
 Homo sapiens
dGMP
-
 Homo sapiens
dTMP
-
 Homo sapiens
d[(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate))3pT]
-
 Homo sapiens
d[(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate))5pT]
-
 Homo sapiens
d[(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate))7pT]
-
 Homo sapiens
d[(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate))9pT]
-
 Homo sapiens
NaH2PO4
-
 Homo sapiens
UMP
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(pT)7(p(2,3-dihydroxy-5-oxopentyl phosphate))(pT)6
-
 Homo sapiens ?
-
 ?
oligodeoxynucleotide with abasic site 2,3-dihydroxy-5-oxopentyl phosphate
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
APE1
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00033
-
 d(pA)10*d(pT)10 pH 7.6, 37°C Homo sapiens
0.00033
-
 d(pA)14*d(pT)14 pH 7.6, 37°C Homo sapiens
0.00033
-
 d(pA)16*d(pT)16 pH 7.6, 37°C Homo sapiens
0.00033
-
 d(pA)20*(pT)20 pH 7.6, 37°C Homo sapiens
0.00036
-
 d(pA)12*d(pT)12 pH 7.6, 37°C Homo sapiens
0.001
-
 d[(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate))9pT] pH 7.6, 37°C Homo sapiens
0.00166
-
 d(pA)10 pH 7.6, 37°C Homo sapiens
0.00166
-
 d(pA)16 pH 7.6, 37°C Homo sapiens
0.0017
-
 d(pA)12 pH 7.6, 37°C Homo sapiens
0.0017
-
 d(pA)14 pH 7.6, 37°C Homo sapiens
0.0023
-
 d[(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate))7pT] pH 7.6, 37°C Homo sapiens
0.0025
-
 d(pT)10 pH 7.6, 37°C Homo sapiens
0.0025
-
 d(pA)8 pH 7.6, 37°C Homo sapiens
0.0025
-
 d(pT)11 pH 7.6, 37°C Homo sapiens
0.0025
-
 d(pT)12 pH 7.6, 37°C Homo sapiens
0.0025
-
 d(pT)14 pH 7.6, 37°C Homo sapiens
0.0025
-
 (pA)10*d(pT)10 pH 7.6, 37°C Homo sapiens
0.0025
-
 (pA)11*d(pT)11 pH 7.6, 37°C Homo sapiens
0.0025
-
 (pA)16*d(pT)16 pH 7.6, 37°C Homo sapiens
0.00257
-
 d(pT)15 pH 7.6, 37°C Homo sapiens
0.0033
-
 d(pC)10 pH 7.6, 37°C Homo sapiens
0.0033
-
 d(pC)11 pH 7.6, 37°C Homo sapiens
0.0033
-
 d(pC)13 pH 7.6, 37°C Homo sapiens
0.0047
-
 d(pC)9 pH 7.6, 37°C Homo sapiens
0.0052
-
 d[(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate))5pT] pH 7.6, 37°C Homo sapiens
0.0054
-
 d(pG)8 pH 7.6, 37°C Homo sapiens
0.0063
-
 (pA)8*d(pT)8 pH 7.6, 37°C Homo sapiens
0.00759
-
 (pA)4*d(pT)4 pH 7.6, 37°C Homo sapiens
0.0083
-
 d(pT)8 pH 7.6, 37°C Homo sapiens
0.0093
-
 d(pA)8*d(pT)8 pH 7.6, 37°C Homo sapiens
0.01
-
 d(pC)7 pH 7.6, 37°C Homo sapiens
0.01
-
 (pU)10*(pA)10 pH 7.6, 37°C Homo sapiens
0.01
-
 (pU)16*(pA)16 pH 7.6, 37°C Homo sapiens
0.0117
-
 d[(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate))3pT] pH 7.6, 37°C Homo sapiens
0.0118
-
 d(pA)6*d(pT)6 pH 7.6, 37°C Homo sapiens
0.0144
-
 d(pG)6 pH 7.6, 37°C Homo sapiens
0.0166
-
 (pU)6*(pA)6 pH 7.6, 37°C Homo sapiens
0.0167
-
 (pU)9*(pA)9 pH 7.6, 37°C Homo sapiens
0.0172
-
 d(pA)6 pH 7.6, 37°C Homo sapiens
0.0214
-
 (pA)6*d(pT)6 pH 7.6, 37°C Homo sapiens
0.0217
-
 d(pC)5 pH 7.6, 37°C Homo sapiens
0.0246
-
 d(pT)6 pH 7.6, 37°C Homo sapiens
0.025
-
 (p(2,3-dihydroxy-5-oxopentyl phosphate)) pH 7.6, 37°C Homo sapiens
0.0266
-
 d(pA)4*d(pT)4 pH 7.6, 37°C Homo sapiens
0.0267
-
 (pA)10 pH 7.6, 37°C Homo sapiens
0.0269
-
 (pA)9 pH 7.6, 37°C Homo sapiens
0.03
-
 (pA)12 pH 7.6, 37°C Homo sapiens
0.03
-
 (pA)16 pH 7.6, 37°C Homo sapiens
0.033
-
 d(pA)4 pH 7.6, 37°C Homo sapiens
0.0366
-
 d(pA)2*d(pT)2 pH 7.6, 37°C Homo sapiens
0.0367
-
 (pA)8 pH 7.6, 37°C Homo sapiens
0.038
-
 (pC)14 pH 7.6, 37°C Homo sapiens
0.0383
-
 d(pG)4 pH 7.6, 37°C Homo sapiens
0.0447
-
 (pC)10 pH 7.6, 37°C Homo sapiens
0.045
-
 d(pT)4 pH 7.6, 37°C Homo sapiens
0.05
-
 d(pA)2 pH 7.6, 37°C Homo sapiens
0.059
-
 d(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate)) pH 7.6, 37°C Homo sapiens
0.06
-
 d(pC)3 pH 7.6, 37°C Homo sapiens
0.0667
-
 d(pT)3 pH 7.6, 37°C Homo sapiens
0.0708
-
 (pC)8 pH 7.6, 37°C Homo sapiens
0.1
-
 (pA)6 pH 7.6, 37°C Homo sapiens
0.102
-
 d(pG)2 pH 7.6, 37°C Homo sapiens
0.1166
-
 d(pT)2 pH 7.6, 37°C Homo sapiens
0.12
-
 (pC)6 pH 7.6, 37°C Homo sapiens
0.135
-
 (pU)4*(pA)4 pH 7.6, 37°C Homo sapiens
0.14
-
 d(pC)2 pH 7.6, 37°C Homo sapiens
0.157
-
 (pU)10 pH 7.6, 37°C Homo sapiens
0.158
-
 (pU)9 pH 7.6, 37°C Homo sapiens
0.158
-
 (pU)16 pH 7.6, 37°C Homo sapiens
0.159
-
 (pU)11 pH 7.6, 37°C Homo sapiens
0.1633
-
 dCMP pH 7.6, 37°C Homo sapiens
0.1633
-
 dTMP pH 7.6, 37°C Homo sapiens
0.165
-
 dAMP pH 7.6, 37°C Homo sapiens
0.1666
-
 dGMP pH 7.6, 37°C Homo sapiens
0.178
-
 (pU)8 pH 7.6, 37°C Homo sapiens
0.183
-
 (pA)4 pH 7.6, 37°C Homo sapiens
0.199
-
 (pA)3 pH 7.6, 37°C Homo sapiens
0.214
-
 (pC)4 pH 7.6, 37°C Homo sapiens
0.263
-
 (pA)2 pH 7.6, 37°C Homo sapiens
0.316
-
 (pC)2 pH 7.6, 37°C Homo sapiens
0.339
-
 (pU)6 pH 7.6, 37°C Homo sapiens
0.36
-
 NaH2PO4 pH 7.6, 37°C Homo sapiens
0.373
-
 AMP pH 7.6, 37°C Homo sapiens
0.447
-
 CMP pH 7.6, 37°C Homo sapiens
0.7
-
 (pU)4 pH 7.6, 37°C Homo sapiens
1.873
-
 UMP pH 7.6, 37°C Homo sapiens