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Literature summary for 4.2.99.18 extracted from

  • Demple, B.; Herman, T.; Chen, D.S.
    Cloning and expression of APE, the cDNA encoding the major human apurinic exonuclease: definition of a family of DNA repair enzymes (1991), Proc. Natl. Acad. Sci. USA, 88, 11450-11454.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA Homo sapiens
-
 fragments of DNA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P27695
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
 Homo sapiens fragments of DNA
-
 ?
additional information enzyme lacks 3'-endonuclease activity against undamaged DNA Homo sapiens ?
-
 ?