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Literature summary for 4.2.3.8 extracted from

  • Kirby, J.; Nishimoto, M.; Park, J.G.; Withers, S.T.; Nowroozi, F.; Behrendt, D.; Rutledge, E.J.; Fortman, J.L.; Johnson, H.E.; Anderson, J.V.; Keasling, J.D.
    Cloning of casbene and neocembrene synthases from Euphorbiaceae plants and expression in Saccharomyces cerevisiae (2010), Phytochemistry, 71, 1466-1473.
    View publication on PubMed

Application

Application Comment Organism
synthesis overexpression of truncated protein in Saccharomyces cerevisiae demonstrates casbene production but also high levels of nerolidol and farnesol and mevalonate Euphorbia esula
synthesis overexpression of truncated protein in Saccharomyces cerevisiae demonstrates casbene production up to 26 mg/l Ricinus communis
synthesis overexpression of truncated protein in Saccharomyces cerevisiae demonstrates casbene production up to 30 mg/l Triadica sebifera

Organism

Organism UniProt Comment Textmining
Euphorbia esula D3JYA2
-
-
Ricinus communis B9RHX4 putative
-
Triadica sebifera D3JYA1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate
-
Euphorbia esula casbene + diphosphate plus neocembrene, approximately 3% of the casbene product ?
geranylgeranyl diphosphate
-
Triadica sebifera casbene + diphosphate plus neocembrene, approximately 3% of the casbene product ?
geranylgeranyl diphosphate
-
Ricinus communis casbene + diphosphate plus neocembrene, approximately 3% of the casbene product ?

Synonyms

Synonyms Comment Organism
TPS2
-
Euphorbia esula
TPS2
-
Triadica sebifera
TPS2
-
Ricinus communis