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Literature summary for 4.2.3.6 extracted from

  • Cane, D.E.; Yang, G.; Xue, Q.; Shim, J.H.
    Trichodiene synthase. Substrate specificity and inhibition (1995), Biochemistry, 34, 2471-2479.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
10-fluorofarnesyl diphosphate
-
Fusarium sporotrichioides
farnesyl diphosphate analogs 10-fluorofarnesyl diphosphate is the most effective competitive inhibitor Fusarium sporotrichioides

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000036
-
(Z,E)-farnesyl diphosphate pH 7.5 Fusarium sporotrichioides
0.000089
-
(3R)-nerolidyl diphosphate pH 7.5 Fusarium sporotrichioides
0.00009
-
(E,E)-farnesyl diphosphate pH 7.5 Fusarium sporotrichioides

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(E,E)-farnesyl diphosphate Fusarium sporotrichioides
-
trichodiene + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Fusarium sporotrichioides
-
recombinant enzyme from Escherichia coli BL21 DE3/pZW03
-
Fusarium sporotrichioides
-
native enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3R)-nerolidyl diphosphate
-
Fusarium sporotrichioides ?
-
?
(E,E)-farnesyl diphosphate
-
Fusarium sporotrichioides trichodiene + diphosphate
-
?
(Z,E)-farnesyl diphosphate
-
Fusarium sporotrichioides ?
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000016
-
10-fluorofarnesyl diphosphate pH 7.5 Fusarium sporotrichioides