Literature summary for 4.2.3.18 extracted from

Peters, R.J.; Ravn, M.M.; Coates, R.M.; Croteau, R.B.
Bifunctional abietadiene synthase: Free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites (2001), J. Am. Chem. Soc., 123, 8974-8978.

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Protein Variants

Protein Variants	Comment	Organism
D404A	unreactive with geranylgeranyl diphosphate	Abies grandis
D621A	unreactive with (+)-copalyl diphosphate	Abies grandis

Inhibitors

Inhibitors	Comment	Organism	Structure
14,15-dihydro-15-azageranylgeranyl diphosphate	-	Abies grandis
geranylgeranyl diphosphate	substrate inhibition	Abies grandis

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00035	-	copalyl diphosphate	-	Abies grandis
0.0004	-	copalyl diphosphate	D404A	Abies grandis
132	-	copalyl diphosphate	-	Abies grandis
138	-	copalyl diphosphate	mutant D404A	Abies grandis

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
90000	-	gel filtration	Abies grandis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(+)-copalyl-diphosphate	Abies grandis	-	(-)-abietadiene + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Abies grandis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(+)-copalyl-diphosphate	-	Abies grandis	(-)-abietadiene + diphosphate	-	?

Subunits

Subunits	Comment	Organism
monomer	-	Abies grandis

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Release 2023.1 (January 2023)