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Literature summary for 4.2.3.17 extracted from

  • Koepp, A.E.; Hezari, M.; Zajicek, J.; Stofer Vogel, B.; LaFever, R.; Lewis, N.G.; Croteau, R.
    Cyclization of geranylgeranyl diphosphateto taxa-4(5),-11(12)-diene is the comitted step of taxol biosynthesis in pacific yew (1995), J. Biol. Chem., 270, 8686-8690.
    View publication on PubMed

Application

Application Comment Organism
medicine chemotherapeutic agent against a range of cancers, including ovarian and breast cancer Taxus brevifolia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranylgeranyl diphosphate Taxus brevifolia catalyzes the first step in taxol biosynthesis taxa-4,11-diene + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Taxus brevifolia
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
stem
-
Taxus brevifolia
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate
-
Taxus brevifolia taxa-4(5),11(12)-diene + diphosphate
-
?
geranylgeranyl diphosphate catalyzes the first step in taxol biosynthesis Taxus brevifolia taxa-4,11-diene + diphosphate
-
?