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Literature summary for 4.2.3.146 extracted from
- Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster affordxa0a diterpene cyclase and two P450 hydroxylases (2009), Chem. Biol., 16, 736-743 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression of the cyclooctatin biosynthetic gene cluster in Escherichia coli | Streptomyces melanosporofaciens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 78000 | - |
gel filtration | Streptomyces melanosporofaciens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| geranylgeranyl diphosphate + H2O | Streptomyces melanosporofaciens | - |
cyclooctat-9-en-7-ol + diphosphate | - |
? |  |
| geranylgeranyl diphosphate + H2O | Streptomyces melanosporofaciens M1614-43f2 | - |
cyclooctat-9-en-7-ol + diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces melanosporofaciens | C9K1X5 | - |
- |
| Streptomyces melanosporofaciens M1614-43f2 | C9K1X5 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| geranylgeranyl diphosphate + H2O | - |
Streptomyces melanosporofaciens | cyclooctat-9-en-7-ol + diphosphate | - |
? | |
| geranylgeranyl diphosphate + H2O | the enzyme is involved in biosynthesis of cyclooctatin | Streptomyces melanosporofaciens | cyclooctat-9-en-7-ol + diphosphate | - |
? | |
| geranylgeranyl diphosphate + H2O | - |
Streptomyces melanosporofaciens M1614-43f2 | cyclooctat-9-en-7-ol + diphosphate | - |
? | |
| geranylgeranyl diphosphate + H2O | the enzyme is involved in biosynthesis of cyclooctatin | Streptomyces melanosporofaciens M1614-43f2 | cyclooctat-9-en-7-ol + diphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 34000, SDS-PAGE | Streptomyces melanosporofaciens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CotB2 | - |
Streptomyces melanosporofaciens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme is involved in biosynthesis of cyclooctatin | Streptomyces melanosporofaciens |
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