Literature summary for 4.2.3.13 extracted from

Yoshikuni, Y.; Martin, V.J.; Ferrin, T.E.; Keasling, J.D.
Engineering cotton (+)-delta -cadinene synthase to an altered function: germacrene D-4-ol synthase (2006), Chem. Biol., 13, 91-98.

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Protein Variants

Protein Variants	Comment	Organism
L405H	mutation alters product selectivity from (+)-d-cadinene to germacrene D-4-ol (53%). Mutation improves the solubility of the enzyme	Gossypium hirsutum
N403P	mutation significantly alters the product selectivity to germacrene D-4-ol (52%)	Gossypium hirsutum
N403P/L405H	mutant maintains its specific activity and shows higher selectivity to germacrene D-4-ol in vivo (up to 93%)	Gossypium hirsutum

Organism

Organism	UniProt	Comment	Textmining
Gossypium hirsutum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-trans,6-trans-farnesyl diphosphate	-	Gossypium hirsutum	(+)-delta-cadinene + diphosphate	-	?

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Release 2023.1 (January 2023)