Application | Comment | Organism |
---|---|---|
medicine | lack of tetrahydrobiopterin leads to hyperphenylalaninemia and a deficiency of biogenic amine neurotransmitters such as dopamine and serotonin and severe progressive mental retardation | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cloned in Escherichia coli | Rattus norvegicus |
expression in Escherichia coli | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens | |
Mg2+ | required | Rattus norvegicus | |
Zn2+ | - |
Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
16000 | - |
5 * 16000, SDS-PAGE | Homo sapiens |
16000 | - |
x * 16000, SDS-PAGE and electrospray ionization-mass spectometry | Homo sapiens |
16257 | - |
5 * 16257, electrospray ionization-mass spectrometry | Homo sapiens |
83000 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin | Homo sapiens | the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway | 6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate | - |
? | |
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin | Rattus norvegicus | the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway | 6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
cloned in Escherichia coli | - |
Purification (Comment) | Organism |
---|---|
affinity chromatography, gel filtration, SDS-PAGE | Homo sapiens |
affinity chromatography, gel filtration, SDS-PAGE | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0574 | - |
- |
Homo sapiens |
57.4 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin | - |
Homo sapiens | 6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate | - |
? | |
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin | - |
Rattus norvegicus | 6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate | - |
? | |
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin | the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway | Homo sapiens | 6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate | - |
? | |
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin | the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway | Rattus norvegicus | 6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | - |
Rattus norvegicus |
? | x * 16000, SDS-PAGE and electrospray ionization-mass spectometry | Homo sapiens |
pentamer | 5 * 16000, SDS-PAGE | Homo sapiens |
pentamer | 5 * 16257, electrospray ionization-mass spectrometry | Homo sapiens |