Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.2.20 extracted from

  • Chen, X.R.; Liao, S.J.; Ye, L.X.; Gong, Q.; Ding, Q.; Zeng, J.S.; Yu, J.
    Neuroprotective effect of chondroitinase ABC on primary and secondary brain injury after stroke in hypertensive rats (2014), Brain Res., 1543, 324-333.
    View publication on PubMed

Application

Application Comment Organism
medicine role of chondroitinase ABC in the primary and secondary injury post stroke in hypertension. Renovascular hypertensive Sprague-Dawley rats underwent middle cerebral artery occlusion, and were subjected to continuous intra-infarct infusion of chondroitinase ABC for 7 days 24 h later. The intra-infarct infusion of chondroitinase ABC, by degrading accumulated chondroitin sulfate proteoglycans, rescues neuronal loss and increases the levels of growth-associated protein GAP-43 and synaptophysin in both the ipsilateral cortex and ventroposterior thalamic nucleus, indicating enhancd neuron survival as well as augmented axonal growth and synaptic plasticity, eventually improving overall neurological function Proteus vulgaris

Organism

Organism UniProt Comment Textmining
Proteus vulgaris
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining