Application | Comment | Organism |
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medicine | role of chondroitinase ABC in the primary and secondary injury post stroke in hypertension. Renovascular hypertensive Sprague-Dawley rats underwent middle cerebral artery occlusion, and were subjected to continuous intra-infarct infusion of chondroitinase ABC for 7 days 24 h later. The intra-infarct infusion of chondroitinase ABC, by degrading accumulated chondroitin sulfate proteoglycans, rescues neuronal loss and increases the levels of growth-associated protein GAP-43 and synaptophysin in both the ipsilateral cortex and ventroposterior thalamic nucleus, indicating enhancd neuron survival as well as augmented axonal growth and synaptic plasticity, eventually improving overall neurological function | Proteus vulgaris |
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Proteus vulgaris | - |
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