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Literature summary for 4.2.2.20 extracted from

  • Cafferty, W.B.; Bradbury, E.J.; Lidierth, M.; Jones, M.; Duffy, P.J.; Pezet, S.; McMahon, S.B.
    Chondroitinase ABC-mediated plasticity of spinal sensory function (2008), J. Neurosci., 28, 11998-12009.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine adult rats that undergo unilateral cervical spared-root lesion exhibit profound sensory deficits for 4 weeks after injury. Delivery of a focal intraspinal injection of the chondroitin sulfate proteoglycan-degrading enzyme chondroitinase ABC (ChABC) is sufficient to restore sensory function after lesion. In vivo electrophysiological recordings confirm that behavioral recovery observed in ChABC-treated rats is consequent on reorganization of intact C7 primary afferent terminals and not regeneration of rhizotomized afferents back into the spinal cord within adjacent segments. These data confirm that intact spinal circuits have a profound influence on functional restoration after spinal cord injury Proteus vulgaris

Organism

Organism UniProt Comment Textmining
Proteus vulgaris
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Synonyms

Synonyms Comment Organism
chondroitinase ABC
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Proteus vulgaris