Literature summary for 4.2.2.20 extracted from

Lin, R.; Kwok, J.C.; Crespo, D.; Fawcett, J.W.
Chondroitinase ABC has a long-lasting effect on chondroitin sulphate glycosaminoglycan content in the injured rat brain (2008), J. Neurochem., 104, 400-408.

Search for more literature for 4.2.2.20

Application

Application	Comment	Organism
medicine	immediate and long-term effects of a single injection of chABC on chondroitin sulphate proteoglycans, chondroitin sulphate glycosaminoglycan and axon regeneration after unilateral nigrostriatal lesions in adult rats are investigated. In chABC-treated animals, the total chondroitin sulphate glycosaminoglycan remain at low level throughout the 28 day experimental period. This suggests the persistence of active chABC for at least 10 days after injection which is able to digest chondroitin sulphate proteoglycans released from cells during this time. Results suggest that a single injection of chABC can produce an environment conducive to CNS repair for over 10 days	Proteus vulgaris

Organism

Organism	UniProt	Comment	Textmining
Proteus vulgaris	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
chABC	-	Proteus vulgaris
chondroitinase ABC	-	Proteus vulgaris

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)