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Literature summary for 4.2.2.20 extracted from
- Mechanisms of cartilage growth. Modulation of balance between proteoglycan and collagen in vitro using chondroitinase ABC (2007), Arthritis Rheum., 56, 188-198.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | incubation of immature articular cartilage in serum-supplemented medium results in expansive growth with a marked increase in tissue volume associated with diminution of tensile integritiy. Treatment with chondroitinase ABC on day 0 leads to a marked reduction of glycosaminoglycan content and enhancement of tensile integrity. Subsequent incubation with enzyme leads to maturational growth with minimal changes in tissue volume and maintenance of tensile intregrity at the enhanced levels | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| articular cartilage | immature articular cartilage explants from the superficial and middle layers. Manipulation of glycosaminoglycan content can distinctly alter the growth phenotype of cartilage | Bos taurus | - |
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Release 2023.1 (January 2023)
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