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Literature summary for 4.2.2.1 extracted from
- Inhibition of hyaluronidases and chondroitinases by fatty acids (2002), J. Enzyme Inhib. Med. Chem., 17, 183-186.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (13Z)-docos-13-enoic acid | strong inhibition | Streptococcus dysgalactiae |  |
| (13Z)-docos-13-enoic acid | weak inhibition | Streptomyces hyalurolytics | |
| arachidic acid | weak inhibition | Streptococcus dysgalactiae | |
| arachidic acid | weak inhibition | Streptomyces hyalurolytics | |
| behenic acid | weak inhibition | Streptococcus dysgalactiae | |
| behenic acid | weak inhibition | Streptomyces hyalurolytics | |
| capric acid | weak inhibition | Streptococcus dysgalactiae | |
| capric acid | weak inhibition | Streptomyces hyalurolytics | |
| eicosadienoic acid | strong inhibition | Streptococcus dysgalactiae | |
| eicosadienoic acid | weak inhibition | Streptomyces hyalurolytics | |
| eicosanoic acid | strong inhibition | Streptococcus dysgalactiae | |
| eicosanoic acid | weak inhibition | Streptomyces hyalurolytics | |
| eicosapentaenoic acid | strong inhibition | Streptococcus dysgalactiae | |
| eicosapentaenoic acid | weak inhibition | Streptomyces hyalurolytics | |
| eicosatetraenoic acid | strong inhibition | Streptococcus dysgalactiae | |
| eicosatetraenoic acid | weak inhibition | Streptomyces hyalurolytics | |
| eicosatrienoic acid | strong inhibition | Streptococcus dysgalactiae | |
| eicosatrienoic acid | weak inhibition | Streptomyces hyalurolytics | |
| elaidic acid | - |
Streptococcus dysgalactiae | |
| elaidic acid | weak inhibition | Streptomyces hyalurolytics | |
| lauric acid | weak inhibition | Streptococcus dysgalactiae | |
| lauric acid | weak inhibition | Streptomyces hyalurolytics | |
| linoleic acid | - |
Streptococcus dysgalactiae | |
| linoleic acid | weak inhibition | Streptomyces hyalurolytics | |
| linolenic acid | - |
Streptococcus dysgalactiae | |
| linolenic acid | weak inhibition | Streptomyces hyalurolytics | |
| methyl (9Z)-octadecenoate | - |
Streptococcus dysgalactiae | |
| methyl (9Z)-octadecenoate | weak inhibition | Streptomyces hyalurolytics | |
| myristic acid | weak inhibition | Streptococcus dysgalactiae | |
| myristic acid | weak inhibition | Streptomyces hyalurolytics | |
| myristoleic acid | - |
Streptococcus dysgalactiae | |
| myristoleic acid | weak inhibition | Streptomyces hyalurolytics | |
| nervonic acid | strong inhibition | Streptococcus dysgalactiae | |
| nervonic acid | weak inhibition | Streptomyces hyalurolytics | |
| oleic acid | - |
Streptococcus dysgalactiae | |
| oleic acid | weak inhibition | Streptomyces hyalurolytics | |
| palmitic acid | weak inhibition | Streptococcus dysgalactiae | |
| palmitic acid | weak inhibition | Streptomyces hyalurolytics | |
| palmitoleic acid | - |
Streptococcus dysgalactiae | |
| palmitoleic acid | weak inhibition | Streptomyces hyalurolytics | |
| petroselinic acid | strong inhibition | Streptococcus dysgalactiae | |
| petroselinic acid | weak inhibition | Streptomyces hyalurolytics | |
| ricinoleic acid | - |
Streptococcus dysgalactiae | |
| ricinoleic acid | weak inhibition | Streptomyces hyalurolytics | |
| stearic acid | weak inhibition | Streptococcus dysgalactiae | |
| stearic acid | weak inhibition | Streptomyces hyalurolytics | |
| vaccenic acid | strong inhibition | Streptococcus dysgalactiae | |
| vaccenic acid | weak inhibition | Streptomyces hyalurolytics | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptococcus dysgalactiae | - |
- |
- |
| Streptomyces hyalurolytics | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| [hyaluronate]n = (4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine-[hyaluronate]n-m-1 + 2 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + hyaluronate | also acts on chondroitin, the product is more systematically known as 3-(4-deoxy-alpha-L-threo-hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose | Streptococcus dysgalactiae | |
| [hyaluronate]n = (4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine-[hyaluronate]n-m-1 + 2 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + hyaluronate | also acts on chondroitin, the product is more systematically known as 3-(4-deoxy-alpha-L-threo-hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose | Streptomyces hyalurolytics |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| hyaluronic acid | from pig skin | Streptococcus dysgalactiae | ? | - |
? | |
| hyaluronic acid | from pig skin | Streptomyces hyalurolytics | 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| h-SD | - |
Streptococcus dysgalactiae |
| h-SH | - |
Streptomyces hyalurolytics |
| hyaluronidase SD | - |
Streptococcus dysgalactiae |
| hyaluronidase SH | - |
Streptomyces hyalurolytics |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Streptococcus dysgalactiae |
| 60 | - |
assay at | Streptomyces hyalurolytics |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.2 | - |
phosphate buffer, assay at | Streptococcus dysgalactiae |
| 6.2 | - |
phosphate buffer, assay at | Streptomyces hyalurolytics |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Streptococcus dysgalactiae | |
| additional information | - |
additional information | - |
Streptomyces hyalurolytics |
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