Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.1.98 extracted from

  • Watkins, W.E.; Glass, T.L.
    Characteristics of 16-dehydroprogesterone reductase in cell extracts of the intestinal anaerobe, Eubacterium sp. strain 144 (1991), J. Steroid Biochem. Mol. Biol., 38, 257-263.
    View publication on PubMed
Search for more literature for 4.2.1.98

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by inhibitors of electron transport reactions or metal chelators Eubacterium sp.
sulfhydryl reagent
-
 Eubacterium sp.
Tris-HCl at pH above 7 Eubacterium sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm 40% activity in cytoplasmic, 20% in membrane fractions of crude cell extract Eubacterium sp. 5737
-
membrane 40% activity in cytoplasmic, 20% in membrane fractions of crude cell extract Eubacterium sp. 16020
-

Organism

Organism UniProt Comment Textmining
Eubacterium sp.
-
-
-
Eubacterium sp. 144
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
16-dehydroprogesterone + H2O pyruvate or sodium dithionite serve as electron donors, both reactions require methylviologen as electron carrier Eubacterium sp. 16alpha-hydroxyprogesterone
-
 ?
16-dehydroprogesterone + H2O pyruvate or sodium dithionite serve as electron donors, both reactions require methylviologen as electron carrier Eubacterium sp. 144 16alpha-hydroxyprogesterone
-
 ?

pH Range

pH Minimum pH Maximum Comment Organism
5 8.5 enzyme activity is not affected over this range in potassium phosphate buffer, but is inhibited by Tris-HCl buffer at pH above 7.0 Eubacterium sp.