Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Quinoid 6(S)-methyldihydropterin | - |
Rattus norvegicus | |
Quinoid 6(S)-propyldihydropterin | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0015 | - |
4a(R)-hydroxy-6(S)-propyltetrahydropterin | pH 8.4 or pH 7.4 | Rattus norvegicus | |
0.0025 | - |
4a-Hydroxy-6(S)-methyltetrahydropterin | pH 8.4 or pH 7.4 | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | contains no metals | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | the enzyme is essential in vivo to prevent rearrangement of 4a-hydroxy-6(R)-tetrahydrobiopterin and to maintain the supply of tetrahydrobiopterin cofactor for hydroxylases under conditions where the nonenzymatic rate would be inadequate | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4a(R)-hydroxy-6(S)-propyltetrahydropterin | - |
Rattus norvegicus | quinoid 6(S)-propyldihydropterin | - |
? | |
4a-Hydroxy-6(R)-dihydroxypropyltetrahydropterin | - |
Rattus norvegicus | ? | - |
? | |
4a-Hydroxy-6(S)-methyltetrahydropterin | - |
Rattus norvegicus | Quinoid 6(S)-methyldihydropterin | - |
? | |
4a-Hydroxy-6(S)-propyltetrahydropterin | - |
Rattus norvegicus | Quinoid 6(S)-propyldihydropterin | - |
? | |
additional information | the enzyme is essential in vivo to prevent rearrangement of 4a-hydroxy-6(R)-tetrahydrobiopterin and to maintain the supply of tetrahydrobiopterin cofactor for hydroxylases under conditions where the nonenzymatic rate would be inadequate | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme has identical amino acid sequence to DCoH, the dimerization cofactor of the transcription regulator, HNF-1alpha | Rattus norvegicus |